Systemic and Ocular Associations of Keratoconus.

IF 0.9 Q4 OPHTHALMOLOGY

Expert Review of Ophthalmology Pub Date : 2024-01-01 Epub Date: 2024-07-03 DOI:10.1080/17469899.2024.2368801

Brenna S Hefley, Arsalan A Ali, Pradipta Bhattacharya, Jesper Hjortdal, Maria K Walker, Dimitrios Karamichos

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引用次数: 0

Abstract

Introduction: Keratoconus (KC) is the most prevalent corneal ectasia in the world and its pathogenesis is influenced by both ocular and systemic factors. This review explores the multifaceted associations between keratoconus and systemic health conditions, ocular characteristics, and various other environmental/exogenous factors, aiming to illuminate how these relationships influence the pathophysiology of the disease.

Areas covered: This review will summarize the fundamental attributes of KC, review and discuss the systemic and ocular association of KC including molecular biomarkers, and provide an organized overview of the parallel alterations occurring within various biological pathways in KC.

Expert opinion: Despite the substantial volume of research on keratoconus, the precise etiology of the disease remains elusive. Further studies are necessary to deepen our understanding of this intricate disorder and improve its management.

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角膜炎的全身和眼部关联。

导言：角膜炎（Keratoconus，KC）是世界上发病率最高的角膜异位症，其发病机制受到眼部和全身因素的影响。本综述探讨了角膜塑形镜与全身健康状况、眼部特征以及其他各种环境/外在因素之间的多方面关联，旨在阐明这些关系如何影响该疾病的病理生理学：本综述将总结角膜病的基本特征，回顾和讨论角膜病与全身和眼部的关联，包括分子生物标志物，并对角膜病中各种生物通路发生的平行改变进行有条理的概述：尽管对角膜炎进行了大量研究，但该疾病的确切病因仍然难以捉摸。为了加深我们对这种错综复杂的疾病的了解并改善其治疗，有必要开展进一步的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Ophthalmology Health Professions-Optometry

CiteScore

1.40

自引率

0.00%

发文量

期刊介绍： The worldwide problem of visual impairment is set to increase, as we are seeing increased longevity in developed countries. This will produce a crisis in vision care unless concerted action is taken. The substantial value that ophthalmic interventions confer to patients with eye diseases has led to intense research efforts in this area in recent years, with corresponding improvements in treatment, ophthalmic instrumentation and surgical techniques. As a result, the future for ophthalmology holds great promise as further exciting and innovative developments unfold.