Hypoxic Responses in Periodontal Tissues: Influence of Smoking and Periodontitis.

IF 5.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Clinical Periodontology Pub Date : 2024-11-03 DOI:10.1111/jcpe.14087

Bejna Bozyel, Özlem Doğan, Serenay Elgün, Burcu Özdemir

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引用次数: 0

Abstract

Aim: This study aimed to investigate the hypoxic changes in periodontal tissues resulting from smoking and periodontitis by assessing levels of hypoxia-inducible factors (HIF-1α, HIF-2α, HIF-3α) and vascular endothelial growth factor (VEGF) in gingival crevicular fluid (GCF).

Materials and methods: The study comprised 22 periodontally healthy non-smokers (Group H), 22 periodontally healthy smokers (Group HS), 22 non-smokers with periodontitis (Group P) and 22 smokers with periodontitis (Group PS). Clinical periodontal parameters were documented, and GCF samples were collected and analysed using enzyme-linked immunosorbent assay (ELISA).

Results: Significantly elevated levels of HIF-1α, HIF-3α and VEGF were observed in Groups HS, P and PS compared to Group H (p < 0.05). Moreover, higher HIF-2α levels were detected in the Groups HS and P compared to Group H (p < 0.05). Significant correlations were detected between all evaluated hypoxia biomarkers in the Group P (p < 0.05) except HIF-2α and HIF-3α. However, in the PS group, significant correlation appeared only between HIF-1α and HIF-2α (p < 0.05).

Conclusion: Our findings indicate that smoking and periodontitis induce comparable hypoxic effects in periodontal tissues, as evidenced by the evaluated biomarkers. Further research is warranted to gain a deeper understanding of the mechanisms underlying hypoxia in periodontal tissues.

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牙周组织的缺氧反应：吸烟和牙周炎的影响

目的：本研究旨在通过评估龈沟液（GCF）中缺氧诱导因子（HIF-1α、HIF-2α、HIF-3α）和血管内皮生长因子（VEGF）的水平，研究吸烟和牙周炎导致的牙周组织缺氧性变化：研究对象包括 22 名牙周健康的非吸烟者（H 组）、22 名牙周健康的吸烟者（HS 组）、22 名患有牙周炎的非吸烟者（P 组）和 22 名患有牙周炎的吸烟者（PS 组）。记录临床牙周参数，收集 GCF 样本并使用酶联免疫吸附试验（ELISA）进行分析：结果：与 H 组相比，HS 组、P 组和 PS 组的 HIF-1α、HIF-3α 和 VEGF 水平明显升高（p 结论：我们的研究结果表明，吸烟与牙周病密切相关：我们的研究结果表明，吸烟和牙周炎会对牙周组织产生类似的缺氧效应，评估的生物标志物也证明了这一点。为了更深入地了解牙周组织缺氧的内在机制，有必要开展进一步的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Periodontology 医学-牙科与口腔外科

CiteScore

13.30

自引率

10.40%

发文量

175

审稿时长

3-8 weeks

期刊介绍： Journal of Clinical Periodontology was founded by the British, Dutch, French, German, Scandinavian, and Swiss Societies of Periodontology. The aim of the Journal of Clinical Periodontology is to provide the platform for exchange of scientific and clinical progress in the field of Periodontology and allied disciplines, and to do so at the highest possible level. The Journal also aims to facilitate the application of new scientific knowledge to the daily practice of the concerned disciplines and addresses both practicing clinicians and academics. The Journal is the official publication of the European Federation of Periodontology but wishes to retain its international scope. The Journal publishes original contributions of high scientific merit in the fields of periodontology and implant dentistry. Its scope encompasses the physiology and pathology of the periodontium, the tissue integration of dental implants, the biology and the modulation of periodontal and alveolar bone healing and regeneration, diagnosis, epidemiology, prevention and therapy of periodontal disease, the clinical aspects of tooth replacement with dental implants, and the comprehensive rehabilitation of the periodontal patient. Review articles by experts on new developments in basic and applied periodontal science and associated dental disciplines, advances in periodontal or implant techniques and procedures, and case reports which illustrate important new information are also welcome.