Deciphering the CNS-glioma dialogue: Advanced insights into CNS-glioma communication pathways and their therapeutic potential.

IF 2.6 Q2 CLINICAL NEUROLOGY
Journal of Central Nervous System Disease Pub Date : 2024-10-23 eCollection Date: 2024-01-01 DOI:10.1177/11795735241292188
Lu Zhang, Yajing Wang, Xiaoxi Cai, Xinyuan Mao, Haitao Sun
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引用次数: 0

Abstract

The field of cancer neuroscience has rapidly evolved, shedding light on the complex interplay between the nervous system and cancer, with a particular focus on the relationship between the central nervous system (CNS) and gliomas. Recent advancements have underscored the critical influence of CNS activity on glioma progression, emphasizing the roles of neurons and neuroglial cells in both the onset and evolution of gliomas. This review meticulously explores the primary communication pathways between the CNS and gliomas, encompassing neuro-glioma synapses, paracrine mechanisms, extracellular vesicles, tunneling nanotubes, and the integrative CNS-immune-glioma axis. It also evaluates current and emerging therapeutic interventions aimed at these pathways and proposes forward-looking perspectives for research in this domain.

解密中枢神经系统-胶质瘤对话:中枢神经系统-胶质瘤沟通途径及其治疗潜力的先进见解。
癌症神经科学领域发展迅速,揭示了神经系统与癌症之间复杂的相互作用,尤其关注中枢神经系统(CNS)与胶质瘤之间的关系。最近的研究进展强调了中枢神经系统活动对胶质瘤进展的重要影响,强调了神经元和神经胶质细胞在胶质瘤发病和演变过程中的作用。这篇综述细致地探讨了中枢神经系统与胶质瘤之间的主要沟通途径,包括神经-胶质瘤突触、旁分泌机制、细胞外囊泡、隧道纳米管以及中枢神经系统-免疫-胶质瘤综合轴。报告还评估了针对这些途径的现有和新兴治疗干预措施,并对该领域的研究提出了前瞻性展望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
6.90
自引率
0.00%
发文量
39
审稿时长
8 weeks
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