Arrhythmogenicity of monophasic and biphasic PFA waveforms in a porcine model

IF 2.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Cardiovascular Electrophysiology Pub Date : 2024-11-03 DOI:10.1111/jce.16480

Hanife Tugba Kumru PhD, Lars Mattison PhD, Khaldoun G. Tarakji MD, MPH, Atul Verma MD, Daniel C. Sigg MD, PhD

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Abstract

Objective

The potential risk of inducing ventricular arrhythmias was explored by employing pulsed field ablation (PFA) through the administration of both monophasic and biphasic waveform deliveries.

Methods

PFA was applied to specific locations in the right ventricle (RV, n = 5 sites) in swine (n = 2), utilizing identical settings with consistent amplitude, pulse width, and a number of pulses for both monophasic and biphasic waveforms. PFA deliveries were precisely timed in 10-ms intervals across the entire T wave.

Results

Using monophasic waveforms, ventricular fibrillation (VF) was induced 7/7 times when PFA pulses were delivered during the T wave. Biphasic waveforms resulted in no ventricular arrhythmias when PFA was delivered across the entire duration of T wave.

Conclusions

Our findings indicate that VF can be consistently induced with monophasic pulse waveforms, but not with biphasic pulse waveforms in a porcine model.

Abstract Image

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猪模型中单相和双相 PFA 波形的致心律失常性。

目的：通过使用单相和双相波形输送脉冲场消融（PFA），探讨诱发室性心律失常的潜在风险：将 PFA 应用于猪右心室（RV，n = 5 个部位）的特定位置（n = 2），单相和双相波形均采用相同的设置，具有一致的振幅、脉宽和脉冲数。在整个 T 波中，PFA 输送的时间间隔为 10 毫秒：结果：使用单相波形，在 T 波期间发放 PFA 脉冲时，诱发室颤（VF）的次数为 7/7。结论：我们的研究结果表明，在 T 波的整个持续时间内输送 PFA 脉冲时，双相波形不会导致室性心律失常：我们的研究结果表明，在猪模型中，单相脉冲波形可以持续诱发室颤，而双相脉冲波形则不能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cardiovascular Electrophysiology 医学-心血管系统

CiteScore

5.20

自引率

14.80%

发文量

433

审稿时长

3-6 weeks

期刊介绍： Journal of Cardiovascular Electrophysiology (JCE) keeps its readership well informed of the latest developments in the study and management of arrhythmic disorders. Edited by Bradley P. Knight, M.D., and a distinguished international editorial board, JCE is the leading journal devoted to the study of the electrophysiology of the heart.