Garcinia flavonoids for healthy aging: Anti-senescence mechanisms and cosmeceutical applications in skin care

IF 2.5 3区 医学 Q3 CHEMISTRY, MEDICINAL
Idris Adewale Ahmed , Nor Hisam Zamakshshari , Maryam Abimbola Mikail , Ibrahim Bello , Md. Sanower Hossain
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引用次数: 0

Abstract

Cellular senescence, the irreversible arrest of cell division, is a hallmark of aging and a key contributor to age-related disorders. Targeting senescent cells represents a promising therapeutic approach to combat these ailments. This review explores the potential of Garcinia species, a genus rich in flavonoids with established antioxidant and anti-inflammatory properties, as a source of natural anti-senescence agents. We investigate the intricate connections between aging, cellular senescence, and oxidative stress, highlighting the detrimental effects of free radicals on cellular health. Furthermore, we analyze the diverse array of flavonoids identified within Garcinia and their established cellular mechanisms. We critically evaluate the emerging evidence for the anti-senescence potential of flavonoids in general and the limited research on Garcinia flavonoids in this context. By identifying existing knowledge gaps and paving the way for future research, this review underscores the exciting potential of Garcinia flavonoids as natural anti-senescence agents. These agents hold promise for not only promoting healthy aging but also for the development of cosmeceutical products that combat the visible signs of aging.

Abstract Image

促进健康老龄化的藤黄类化合物:抗衰老机制和药用护肤品的应用。
细胞衰老是细胞分裂不可逆转的停滞,是衰老的标志,也是导致老年相关疾病的关键因素。以衰老细胞为靶点是一种很有前景的治疗方法。藤黄属植物富含黄酮类化合物,具有公认的抗氧化和抗炎特性,本综述探讨了藤黄属植物作为天然抗衰老剂来源的潜力。我们研究了衰老、细胞衰老和氧化应激之间错综复杂的联系,强调了自由基对细胞健康的有害影响。此外,我们还分析了在藤黄属植物中发现的各种类黄酮及其既定的细胞机制。我们批判性地评估了黄酮类化合物抗衰老潜力的新证据,以及在此背景下有关藤黄属植物黄酮类化合物的有限研究。通过确定现有的知识差距和为未来研究铺平道路,本综述强调了加西黄酮类化合物作为天然抗衰老剂的令人兴奋的潜力。这些制剂不仅有望促进健康老龄化,而且有望开发出能消除明显衰老迹象的药用化妆品。
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来源期刊
Fitoterapia
Fitoterapia 医学-药学
CiteScore
5.80
自引率
2.90%
发文量
198
审稿时长
1.5 months
期刊介绍: Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.
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