The epidermal integrin-mediated secretome regulates the skin microenvironment during tumorigenesis and repair

IF 4.5 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Whitney M. Longmate
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引用次数: 0

Abstract

Integrins are cellular transmembrane receptors that physically connect the cytoskeleton with the extracellular matrix. As such, they are positioned to mediate cellular responses to microenvironmental cues. Importantly, integrins also regulate their own microenvironment through secreted factors, also known as the integrin-mediated secretome. Epidermal integrins, or integrins expressed by keratinocytes of the skin epidermis, regulate the cutaneous microenvironment through the contribution of matrix components, via proteolytic matrix remodeling, or by mediating factors like cytokines and growth factors that can promote support for nearby but distinct cells of the stroma, such as immune cells, endothelial cells, and fibroblasts. This role for integrins is enhanced during both pathological and repair tissue remodeling processes, such as tumor growth and progression and wound healing. This review will discuss examples of how the epithelial integrin-mediated secretome can regulate the tissue microenvironment. Although different epithelial integrins in various contexts will be explored, emphasis will be given to epidermal integrins that regulate the secretome during wound healing and cutaneous tumor progression. Epidermal integrin α3β1 is of particular focus as well, since this integrin has been revealed as a key regulator of the keratinocyte secretome.
表皮整合素介导的分泌组在肿瘤发生和修复过程中调节皮肤微环境。
整合素是细胞跨膜受体,可将细胞骨架与细胞外基质物理连接起来。因此,它们的定位是介导细胞对微环境线索的反应。重要的是,整合素还能通过分泌因子(也称为整合素介导的分泌组)调节自身的微环境。表皮整合素或皮肤表皮角质形成细胞表达的整合素可通过贡献基质成分、蛋白水解基质重塑或介导细胞因子和生长因子等因子来调节皮肤微环境,这些因子可促进对免疫细胞、内皮细胞和成纤维细胞等附近但不同的基质细胞的支持。在肿瘤生长和进展以及伤口愈合等病理和修复组织重塑过程中,整合素的这种作用都会得到加强。本综述将讨论上皮整合素介导的分泌组如何调节组织微环境的实例。虽然将探讨不同上皮整合素在不同情况下的作用,但重点将放在表皮整合素在伤口愈合和皮肤肿瘤进展过程中调节分泌组的作用上。表皮整合素α3β1也是特别关注的重点,因为该整合素已被揭示为角质形成细胞分泌组的关键调节因子。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Matrix Biology
Matrix Biology 生物-生化与分子生物学
CiteScore
11.40
自引率
4.30%
发文量
77
审稿时长
45 days
期刊介绍: Matrix Biology (established in 1980 as Collagen and Related Research) is a cutting-edge journal that is devoted to publishing the latest results in matrix biology research. We welcome articles that reside at the nexus of understanding the cellular and molecular pathophysiology of the extracellular matrix. Matrix Biology focusses on solving elusive questions, opening new avenues of thought and discovery, and challenging longstanding biological paradigms.
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