Sexual dysfunctions in inflammatory bowel disease: role of Mediterranean diet and quality of life.

IF 3.2 2区医学 Q1 ANDROLOGY

Andrology Pub Date : 2024-11-03 DOI:10.1111/andr.13791

Lorenzo Romano, Mariano Fonticelli, Agnese Miranda, Kateryna Priadko, Luigi Napolitano, Felice Crocetto, Biagio Barone, Davide Arcaniolo, Lorenzo Spirito, Celeste Manfredi, Antonietta Gerarda Gravina, Carmine Sciorio, Debora Compare, Raffaele Melina, Dolores Sgambato, Ambrogio Orlando, Silvia Calderone, Olga Maria Nardone, Gerardo Nardone, Paola Caruso, Katherine Esposito, Marco De Sio, Marco Romano, Maria Ida Maiorino

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引用次数: 0

Abstract

Background: Dietary factors and chronic gastrointestinal diseases are frequent determinants of sexual dysfunctions (SD). Whether inflammatory bowel diseases (IBD) are associated with SD is not well known as well as the role of diet and quality of life (QoL).

Objectives: To evaluate the prevalence of SD in a cohort of IBD patients and assess the role of clinical-demographic variables, adherence to Mediterranean diet (MD) and QoL.

Materials and methods: This is a cross-sectional observational study involving 301 patients (134 females and 167 males); 119 had Crohn's Disease and 182 had ulcerative colitis. SD were assessed through the Female Sexual Function Index (FSFI) and the International Index of Erectile Function (IIEF). Adherence to MD was evaluated by the MD Score. QoL was investigated by the 12-item Short-Form Health Survey (SF-12) which yields summary scores of physical (PCS) and mental (MCS) health. Multiple logistic regression was used to identify predictors of SD.

Results: Prevalence of SD in females was 61.9%, while 52.1% of males had erectile dysfunction. No differences in the prevalence of SD were found between CD and UC in both males and females. IBD activity, as defined by patient-reported outcomes, was significantly associated with SD in both sexes. In females, MD adherence score (OR 0.8, 95% CI 0.653-0.974, p = 0.027), PCS (OR = 0.936, CI 95% = 0.891-0.983, p = 0.008), and MCS (OR 0.9, 95% CI 0.906-0.985, p = 0.008) were protective against SD, whereas in males a higher PCS was associated with a lower probability of SD (OR 0.9, 95% CI 0.891-0.978, p = 0.004) DISCUSSION: IBD patients had a significant prevalence of SD which occurred more frequently in females than in males. Disease activity is associated with a higher likelihood of SD in both sexes, whereas dietary factors are differentially associated with SD in males and females. A better QoL is associated with a lower risk of SD.

Conclusion: SD is prevalent among men and women with IBD. Adherence to MD, PCS and MCS in females as well as PCS in males were protective against SD. The assessment of sexual function in IBD patients could be relevant in order to reach an early diagnosis and a timely treatment.

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炎症性肠病的性功能障碍：地中海饮食和生活质量的作用。

背景：饮食因素和慢性胃肠道疾病是性功能障碍（SD）的常见决定因素。炎症性肠病（IBD）是否与性功能障碍有关以及饮食和生活质量（QoL）的作用尚不清楚：评估一组 IBD 患者中 SD 的患病率，并评估临床-人口变量、地中海饮食（Mediterranean diet，MD）和 QoL 的作用：这是一项横断面观察性研究，涉及 301 名患者（134 名女性和 167 名男性）；其中 119 人患有克罗恩病，182 人患有溃疡性结肠炎。SD通过女性性功能指数（FSFI）和国际勃起功能指数（IIEF）进行评估。MD评分评估了MD的依从性。QoL 通过 12 项短式健康调查（SF-12）进行调查，该调查可得出身体健康（PCS）和心理健康（MCS）的总分。多重逻辑回归用于确定 SD 的预测因素：结果：女性的 SD 患病率为 61.9%，而 52.1% 的男性患有勃起功能障碍。CD和UC的SD患病率在男性和女性中均无差异。根据患者报告的结果，男女患者的IBD活动均与SD显著相关。在女性中，MD依从性评分（OR 0.8，95% CI 0.653-0.974，p = 0.027）、PCS（OR = 0.936，CI 95% = 0.891-0.983，p = 0.008）和MCS（OR 0.9，95% CI 0.906-0.985，p = 0.008）对 SD 具有保护作用，而在男性中，较高的 PCS 与较低的 SD 发生概率相关（OR 0.9，95% CI 0.891-0.978，p = 0.004）。男女患者的疾病活动均与更高的 SD 发生率有关，而饮食因素则与男性和女性的 SD 发生率存在差异。较好的生活质量与较低的 SD 风险相关：结论：SD在男性和女性IBD患者中都很普遍。女性坚持MD、PCS和MCS以及男性坚持PCS对SD有保护作用。对 IBD 患者的性功能进行评估有助于早期诊断和及时治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Andrology ANDROLOGY-

CiteScore

9.10

自引率

6.70%

发文量

200

期刊介绍： Andrology is the study of the male reproductive system and other male gender related health issues. Andrology deals with basic and clinical aspects of the male reproductive system (gonads, endocrine and accessory organs) in all species, including the diagnosis and treatment of medical problems associated with sexual development, infertility, sexual dysfunction, sex hormone action and other urological problems. In medicine, Andrology as a specialty is a recent development, as it had previously been considered a subspecialty of urology or endocrinology