Unearthing a prostate cancer cfDNA signature that "stems" from AR alterations.

IF 10 1区医学 Q1 ONCOLOGY

Clinical Cancer Research Pub Date : 2024-11-04 DOI:10.1158/1078-0432.CCR-24-2849

Rashad Nawfal, Razane El Hajj Chehade, Jacob E Berchuck

引用次数: 0

Abstract

Androgen receptor (AR) alterations portend a poor prognosis in patients with advanced prostate cancer. A recent study identified a stemness signature enriched in cell-free DNA from AR-altered patients, associated with worse outcomes. These findings highlight the potential of epigenomic liquid biopsy tools to discover novel clinically relevant tumor molecular subtypes.

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发现 "源于 "AR 改变的前列腺癌 cfDNA 特征。

雄激素受体（AR）改变预示着晚期前列腺癌患者的预后不佳。最近的一项研究发现，在AR改变患者的无细胞DNA中富集的干性特征与较差的预后有关。这些发现凸显了表观基因组液体活检工具发现新型临床相关肿瘤分子亚型的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Cancer Research 医学-肿瘤学

CiteScore

20.10

自引率

1.70%

发文量

1207

审稿时长

2.1 months

期刊介绍： Clinical Cancer Research is a journal focusing on groundbreaking research in cancer, specifically in the areas where the laboratory and the clinic intersect. Our primary interest lies in clinical trials that investigate novel treatments, accompanied by research on pharmacology, molecular alterations, and biomarkers that can predict response or resistance to these treatments. Furthermore, we prioritize laboratory and animal studies that explore new drugs and targeted agents with the potential to advance to clinical trials. We also encourage research on targetable mechanisms of cancer development, progression, and metastasis.