A meningoencephalitis outbreak associated with echovirus type 18 (E18) in south-western Hungary in mid-2023

IF 2.5 4区医学 Q3 VIROLOGY

Archives of Virology Pub Date : 2024-11-04 DOI:10.1007/s00705-024-06166-5

Károly Takáts, Benigna Balázs, Ákos Boros, Dávid Sipos, Zoltán Péterfi, Márk Harmat, Dávid Varga, Zita Zengő-Bedő, Péter Pankovics, Gábor Reuter

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Abstract

Echovirus type 18 (E18) is a member of the genus Enterovirus of the family Picornaviridae. In this study, we investigated the characteristics of E18 infections in hospitalized adults with meningoencephalitis that occurred during an unusual epidemic in south-western Hungary in mid-2023. Five (6.1%) out of 82 cerebrospinal fluid specimens that were tested were positive for an enterovirus, four of which were E18 (OR372160 and PP861087-PP861090). Headache (100%), fever (75%), retrobulbar pain (50%), nausea (50%), joint/limb pain (50%), exanthema, photophobia, and vomiting were the most common symptoms. Sequence analysis showed that these viruses were related to unpublished emerging E18 strains from France (2022/2023) and China (2019/2020). Further study is necessary to monitor the circulation of epidemic/pandemic E18 variants over time.

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2023 年年中，匈牙利西南部爆发了与埃可病毒 18 型（E18）有关的脑膜脑炎疫情。

埃可病毒 18 型（E18）是微小病毒科肠道病毒属的一个成员。在本研究中，我们调查了 2023 年中期匈牙利西南部异常流行期间发生的脑膜脑炎住院成人中 E18 感染的特征。在检测的 82 份脑脊液标本中，有 5 份（6.1%）对肠道病毒呈阳性，其中 4 份为 E18 病毒（OR372160 和 PP861087-PP861090）。头痛（100%）、发热（75%）、球后疼痛（50%）、恶心（50%）、关节/肢体疼痛（50%）、红斑、畏光和呕吐是最常见的症状。序列分析表明，这些病毒与法国（2022/2023 年）和中国（2019/2020 年）未公布的新出现的 E18 株系有关。有必要开展进一步研究，以监测 E18 流行/大流行变异株随着时间推移的流通情况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Virology 医学-病毒学

CiteScore

5.10

自引率

7.40%

发文量

324

审稿时长

4.5 months

期刊介绍： Archives of Virology publishes original contributions from all branches of research on viruses, virus-like agents, and virus infections of humans, animals, plants, insects, and bacteria. Coverage spans a broad spectrum of topics, from descriptions of newly discovered viruses, to studies of virus structure, composition, and genetics, to studies of virus interactions with host cells, organisms and populations. Studies employ molecular biologic, molecular genetics, and current immunologic and epidemiologic approaches. Contents include studies on the molecular pathogenesis, pathophysiology, and genetics of virus infections in individual hosts, and studies on the molecular epidemiology of virus infections in populations. Also included are studies involving applied research such as diagnostic technology development, monoclonal antibody panel development, vaccine development, and antiviral drug development.Archives of Virology wishes to publish obituaries of recently deceased well-known virologists and leading figures in virology.