Features and Differences in Core Symptom Clusters in Home-Based Hospice Patients With Advanced Cancer: A Network Analysis

IF 2.9 2区医学 Q2 ONCOLOGY

Cancer Medicine Pub Date : 2024-11-04 DOI:10.1002/cam4.70370

Yitao Wei, Wan Cheng, Yuanfeng Lu, Zheng Zhu, Guiru Xu, Hong Wu, Shaowei Lin, Huimin Xiao

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引用次数: 0

Abstract

Introduction

Patients with terminal-stage cancer frequently experience multiple symptoms simultaneously. Little is known about how core symptom clusters differ in advanced-cancer patients with different survival expectancies receiving hospice care. To identify the core symptom clusters of hospice-care cancer patients with different survival expectancies and compare the features of their symptom networks.

Methods

In this retrospective study, secondary data analysis was conducted. Records of 6946 patients with advanced cancer who received home-based hospice care service in a hospice center from April 2001 to December 2020 were collected and analyzed using network analysis.

Results

This analysis included 6946 patients with advanced cancer receiving hospice care. In patients with survival expectancies of 0–6 months, loss of appetite was identified as the core symptom (rs = 4.03, rb = 5.21, rc = 2.63), and five symptom clusters were identified. Malnutrition was the core symptom in patients with survival expectancies of 6–12 months (rs = 2.83, rb = 2.43, rc = 0.93), and nine symptom clusters were identified. Wasting syndrome was the core symptom cluster in two groups. The network density of symptoms in patients with < 6 months of survival expectancy (91.99) was higher than in patients with 6–12 months (28.39).

Conclusions

Nutrition impact symptoms are the core symptoms for home-hospice care cancer patients with a survival period of 1 year or below. Moreover, hospice cancer patients with short survival expectancies have greater inter-symptom impact.

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居家安宁疗护晚期癌症患者核心症状群的特征与差异：网络分析。

简介晚期癌症患者经常会同时出现多种症状。人们对接受临终关怀的晚期癌症患者的核心症状集群有何不同知之甚少。目的：确定接受临终关怀的不同预期生存期癌症患者的核心症状群，并比较其症状网络的特征：在这项回顾性研究中，我们对二手数据进行了分析。收集了2001年4月至2020年12月期间在一家临终关怀中心接受居家临终关怀服务的6946名晚期癌症患者的记录，并利用网络分析法对其进行了分析：该分析包括6946名接受安宁疗护的晚期癌症患者。在预期生存期为 0-6 个月的患者中，食欲不振被确定为核心症状（rs = 4.03，rb = 5.21，rc = 2.63），并确定了五个症状群。营养不良是预期存活期为 6-12 个月的患者的核心症状（rs = 2.83，rb = 2.43，rc = 0.93），并确定了 9 个症状群。消瘦综合征是两组患者的核心症状群。结论：营养影响症状是营养不良患者的核心症状：营养影响症状是生存期在 1 年或 1 年以下的居家临终关怀癌症患者的核心症状。此外，预期生存期较短的临终关怀癌症患者的症状间影响更大。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Medicine ONCOLOGY-

CiteScore

5.50

自引率

2.50%

发文量

907

审稿时长

19 weeks

期刊介绍： Cancer Medicine is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research from global biomedical researchers across the cancer sciences. The journal will consider submissions from all oncologic specialties, including, but not limited to, the following areas: Clinical Cancer Research Translational research ∙ clinical trials ∙ chemotherapy ∙ radiation therapy ∙ surgical therapy ∙ clinical observations ∙ clinical guidelines ∙ genetic consultation ∙ ethical considerations Cancer Biology: Molecular biology ∙ cellular biology ∙ molecular genetics ∙ genomics ∙ immunology ∙ epigenetics ∙ metabolic studies ∙ proteomics ∙ cytopathology ∙ carcinogenesis ∙ drug discovery and delivery. Cancer Prevention: Behavioral science ∙ psychosocial studies ∙ screening ∙ nutrition ∙ epidemiology and prevention ∙ community outreach. Bioinformatics: Gene expressions profiles ∙ gene regulation networks ∙ genome bioinformatics ∙ pathwayanalysis ∙ prognostic biomarkers. Cancer Medicine publishes original research articles, systematic reviews, meta-analyses, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented in the paper.