Silver-mediated radical cascade trifluoromethylthiolation/cyclization of benzimidazole derivatives with AgSCF3†

IF 2.9 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2024-10-30 DOI:10.1039/d4ob01582g

Pan Liu , Yang Geng , Dapeng Zou , Yangjie Wu , Yusheng Wu

引用次数: 0

Abstract

A silver-mediated cascade trifluoromethylthiolation/cyclization of unactivated alkenes has been investigated. This strategy employs AgSCF₃ as the trifluoromethylthiolating reagent to obtain a variety of useful trifluoromethylthiolated tricyclic imidazol derivatives in reasonable yields. Preliminary mechanistic studies indicate that the present reaction takes place via a radical process. This method is distinguished by its atom economy, wide functional group compatibility, operational simplicity and product diversity.

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以 AgSCF3 为媒介的苯并咪唑衍生物的银介导自由基级联三氟甲基硫代化/环化反应。

研究了银介导的未活化烯烃的级联三氟甲基硫代/环化反应。该策略采用 AgSCF3 作为三氟甲基硫代试剂，以合理的产率获得了多种有用的三氟甲基硫代三环咪唑衍生物。初步的机理研究表明，本反应是通过自由基过程进行的。该方法具有原子经济性、广泛的官能团兼容性、操作简便性和产品多样性等特点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.