MMP9 and pancreatic cancer.

IF 1.5 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Bratislava Medical Journal-Bratislavske Lekarske Listy Pub Date : 2024-01-01 DOI:10.4149/BLL_2024_110

Veronika Roskovicova, Jana Katuchova, Ivana Vecurkovska, Jana Maslankova, Maria Marekova, Jozef Radonak, Vladimir Katuch

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引用次数: 0

Abstract

Background: Pancreatic carcinoma is one of the most severe oncological diseases of the gastrointestinal tract. At the time of diagnosis, up to 28% of patients have metastatic liver damage, and only 5% of patients survive five years. Scientific research focuses on non-invasive markers that could help screen for the disease and identify patients more quickly. Potential biomarkers also include matrix metalloproteinases, which play a role in oncogenesis.

Material and methods: We prospectively followed 46 patients with pancreatic cancer and benign pancreatic diseases from September 2022 to March 2023. We determined the level of MMP9 in serum and tissue biopsied during surgeries.

Result: As a result, MMP9 levels were elevated from the T2 stage. The correlation between disease stage and MMP9 level was not confirmed in lower stages, possibly due to the small group of patients.

Conclusion: MMP9 seems suitable for detecting late stages of pancreatic cancer, possibly for secondary prevention. We could not confirm a correlation between MMP9 levels and the initial stages of the disease (Tab. 1, Fig. 3, Ref. 21). Text in PDF www.elis.sk Keywords: pancreatic cancer, MMP9, marker, non-invasive, screening.

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MMP9 与胰腺癌

背景：胰腺癌是胃肠道最严重的肿瘤疾病之一。确诊时，多达 28% 的患者会出现肝转移性损伤，只有 5% 的患者能存活五年。科学研究的重点是有助于筛查这种疾病并更快确定患者的非侵入性标记物。潜在的生物标志物还包括在肿瘤发生过程中发挥作用的基质金属蛋白酶：从2022年9月到2023年3月，我们对46名胰腺癌和良性胰腺疾病患者进行了前瞻性随访。我们测定了血清和手术活检组织中的 MMP9 水平：结果：MMP9 水平从 T2 阶段开始升高。结果：MMP9水平从T2期开始升高，但在较低期，疾病分期与MMP9水平之间的相关性未得到证实，这可能是由于患者人数较少所致：结论：MMP9 似乎适用于检测胰腺癌晚期，也可用于二级预防。我们无法证实 MMP9 水平与疾病初期阶段之间存在相关性（表 1，图 3，参考文献 21）。Text in PDF www.elis.sk Keywords: pancreatic cancer, MMP9, marker, non-invasive, screening.

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来源期刊

Bratislava Medical Journal-Bratislavske Lekarske Listy 医学-医学：内科

CiteScore

2.60

自引率

0.00%

发文量

185

审稿时长

3-8 weeks

期刊介绍： The international biomedical journal - Bratislava Medical Journal – Bratislavske lekarske listy (Bratisl Lek Listy/Bratisl Med J) publishes peer-reviewed articles on all aspects of biomedical sciences, including experimental investigations with clear clinical relevance, original clinical studies and review articles.