Association between the triglyceride to high density lipoprotein cholesterol ratio and the incidence of metabolic dysfunction-associated fatty liver disease: a retrospective cohort study.

IF 2.5 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

BMC Gastroenterology Pub Date : 2024-11-01 DOI:10.1186/s12876-024-03471-w

Xiangming Ma, Jianguo Jia, Haozhe Cui, Jing Zhou, Fei Tian, Jingtao Yang, Yali Zhang, Jiaying Dai, Liying Cao

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引用次数: 0

Abstract

Background: The triglyceride to high density lipoprotein cholesterol ratio (TG/HDL-C) is a confirmed predictive factor for insulin resistance and is suggested to be closely related to metabolic dysfunction-associated fatty liver disease (MAFLD), but previous research is inconclusive. The association between TG/HDL-C and MAFLD incidence was further explored in this large-sample, long-term retrospective cohort study.

Methods: Individuals who participated in the Kailuan Group health examination from July 2006 to December 2007 (n = 49,518) were included. Data from anthropometric and biochemical indices, epidemiological surveys, and liver ultrasound examinations were collected and analysed statistically, focusing on the association between TG/HDL-C and the incidence of MAFLD.

Results: During a mean follow-up period of 7.62 ± 3.99 years, 24,838 participants developed MAFLD. The cumulative MAFLD incidence rates associated with the first to fourth quartiles of TG/HDL-C were 59.16%, 65.04%, 71.27%, and 79.28%, respectively. The multivariate Cox proportional hazards regression model revealed that the hazard ratios (HRs) (95% CIs) for MAFLD in the second, third, and fourth quartiles were 1.20 (1.16-1.25), 1.50 (1.45-1.56), and 2.02 (1.95-2.10) (P for trend < 0.05), respectively, and the HR (95% CI) corresponding to an increase of one standard deviation in TG/HDL-C was 1.10 (1.09-1.11) (P < 0.05). Subsequent subgroup and sensitivity analyses yielded results similar to those of the main analyses.

Conclusions: TG/HDL-C is independently associated with MAFLD risk, with higher TG/HDL-C indicating greater MAFLD risk.

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甘油三酯与高密度脂蛋白胆固醇比率与代谢功能障碍相关性脂肪肝发病率之间的关系：一项回顾性队列研究。

背景：甘油三酯与高密度脂蛋白胆固醇比值（TG/HDL-C）是胰岛素抵抗的确证预测因素，并被认为与代谢功能障碍相关性脂肪肝（MAFLD）密切相关，但以往的研究尚无定论。这项大样本、长期回顾性队列研究进一步探讨了 TG/HDL-C 与 MAFLD 发病率之间的关系：方法：纳入 2006 年 7 月至 2007 年 12 月参加开滦集团健康体检的人群（n = 49,518 人）。研究收集了人体测量和生化指标、流行病学调查以及肝脏超声检查的数据，并进行了统计分析，重点研究了TG/HDL-C与MAFLD发病率之间的关系：结果：在平均 7.62 ± 3.99 年的随访期间，有 24 838 名参与者患上了 MAFLD。与 TG/HDL-C 第一至第四四分位数相关的 MAFLD 累计发病率分别为 59.16%、65.04%、71.27% 和 79.28%。多变量 Cox 比例危险回归模型显示，第二、第三和第四四分位数的 MAFLD 危险比（HRs）（95% CIs）分别为 1.20（1.16-1.25）、1.50（1.45-1.56）和 2.02（1.95-2.10）（P 为趋势结论）：TG/HDL-C与MAFLD风险独立相关，TG/HDL-C越高表明MAFLD风险越大。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Gastroenterology 医学-胃肠肝病学

CiteScore

4.20

自引率

0.00%

发文量

465

审稿时长

6 months

期刊介绍： BMC Gastroenterology is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of gastrointestinal and hepatobiliary disorders, as well as related molecular genetics, pathophysiology, and epidemiology.