Post-translational control of B lineage commitment

IF 27.7 1区医学 Q1 IMMUNOLOGY

Nature Immunology Pub Date : 2024-11-01 DOI:10.1038/s41590-024-02019-0

Junli Nie, Ashley P. Ng, Stephen L. Nutt

引用次数: 0

Abstract

PAX5 controls the gene regulatory circuit that leads to B cell lineage commitment. A detailed study shows that the stability of PAX5 protein is reduced by acetylation, and that SIRT7-dependent deacetylation is required for full PAX5 activity.

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B 系遗传的翻译后控制

PAX5 控制着导致 B 细胞系形成的基因调控回路。一项详细的研究表明，PAX5 蛋白的稳定性会因乙酰化而降低，PAX5 的全部活性需要依赖 SIRT7 的去乙酰化作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.