TAM-ing the beast with IL-34 blockade

IF 17.6 1区医学 Q1 IMMUNOLOGY

Science Immunology Pub Date : 2024-11-01 DOI:10.1126/sciimmunol.adu0981

Aron Gyorgypal, Robert M. Anthony

引用次数: 0

Abstract

TP53 mutation triggers IL-34 secretion by cancer stem cells, reprogramming macrophages to suppress T cells and promote tumor immune escape.

查看原文本刊更多论文

用 IL-34 阻断 TAM--野兽

TP53突变引发癌症干细胞分泌IL-34，使巨噬细胞重新编程，从而抑制T细胞，促进肿瘤免疫逃逸。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Science Immunology Immunology and Microbiology-Immunology

CiteScore

32.90

自引率

2.00%

发文量

183

期刊介绍： Science Immunology is a peer-reviewed journal that publishes original research articles in the field of immunology. The journal encourages the submission of research findings from all areas of immunology, including studies on innate and adaptive immunity, immune cell development and differentiation, immunogenomics, systems immunology, structural immunology, antigen presentation, immunometabolism, and mucosal immunology. Additionally, the journal covers research on immune contributions to health and disease, such as host defense, inflammation, cancer immunology, autoimmunity, allergy, transplantation, and immunodeficiency. Science Immunology maintains the same high-quality standard as other journals in the Science family and aims to facilitate understanding of the immune system by showcasing innovative advances in immunology research from all organisms and model systems, including humans.