Nanoparticles and bone microenvironment: a comprehensive review for malignant bone tumor diagnosis and treatment

IF 27.7 1区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Yujing Guan, Wei Zhang, Yuling Mao, Shenglong Li
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引用次数: 0

Abstract

Malignant bone tumors, which are difficult to treat with current clinical strategies, originate from bone tissues and can be classified into primary and secondary types. Due to the specificity of the bone microenvironment, the results of traditional means of treating bone tumors are often unsatisfactory, so there is an urgent need to develop new treatments for malignant bone tumors. Recently, nanoparticle-based approaches have shown great potential in diagnosis and treatment. Nanoparticles (NPs) have gained significant attention due to their versatility, making them highly suitable for applications in bone tissue engineering, advanced imaging techniques, and targeted drug delivery. For diagnosis, NPs enhance imaging contrast and sensitivity by integrating targeting ligands, which significantly improve the specific recognition and localization of tumor cells for early detection. For treatment, NPs enable targeted drug delivery, increasing drug accumulation at tumor sites while reducing systemic toxicity. In conclusion, understanding bone microenvironment and using the unique properties of NPs holds great promise in improving disease management, enhancing treatment outcomes, and ultimately improving the quality of life for patients with malignant bone tumors. Further research and development will undoubtedly contribute to the advancement of personalized medicine in the field of bone oncology.
纳米颗粒与骨微环境:恶性骨肿瘤诊断与治疗综述
恶性骨肿瘤起源于骨组织,可分为原发性和继发性两类,目前的临床策略难以治疗。由于骨微环境的特异性,传统的骨肿瘤治疗手段效果往往不尽如人意,因此,开发新的恶性骨肿瘤治疗方法迫在眉睫。最近,基于纳米粒子的方法在诊断和治疗方面显示出巨大的潜力。纳米粒子(NPs)因其多功能性而备受关注,非常适合应用于骨组织工程、先进成像技术和靶向给药。在诊断方面,纳米粒子通过整合靶向配体提高了成像对比度和灵敏度,从而显著改善了肿瘤细胞的特异性识别和定位,便于早期检测。在治疗方面,纳米粒子可实现靶向给药,增加药物在肿瘤部位的蓄积,同时降低全身毒性。总之,了解骨微环境并利用 NPs 的独特性能,在改善疾病管理、提高治疗效果并最终改善恶性骨肿瘤患者的生活质量方面大有可为。进一步的研究和开发无疑将促进骨肿瘤领域个性化医疗的发展。
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来源期刊
Molecular Cancer
Molecular Cancer 医学-生化与分子生物学
CiteScore
54.90
自引率
2.70%
发文量
224
审稿时长
2 months
期刊介绍: Molecular Cancer is a platform that encourages the exchange of ideas and discoveries in the field of cancer research, particularly focusing on the molecular aspects. Our goal is to facilitate discussions and provide insights into various areas of cancer and related biomedical science. We welcome articles from basic, translational, and clinical research that contribute to the advancement of understanding, prevention, diagnosis, and treatment of cancer. The scope of topics covered in Molecular Cancer is diverse and inclusive. These include, but are not limited to, cell and tumor biology, angiogenesis, utilizing animal models, understanding metastasis, exploring cancer antigens and the immune response, investigating cellular signaling and molecular biology, examining epidemiology, genetic and molecular profiling of cancer, identifying molecular targets, studying cancer stem cells, exploring DNA damage and repair mechanisms, analyzing cell cycle regulation, investigating apoptosis, exploring molecular virology, and evaluating vaccine and antibody-based cancer therapies. Molecular Cancer serves as an important platform for sharing exciting discoveries in cancer-related research. It offers an unparalleled opportunity to communicate information to both specialists and the general public. The online presence of Molecular Cancer enables immediate publication of accepted articles and facilitates the presentation of large datasets and supplementary information. This ensures that new research is efficiently and rapidly disseminated to the scientific community.
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