Advancements and potential of chitosan-genipin complex in biotechnological applications: A comprehensive review

IF 2.7 3区化学 Q2 POLYMER SCIENCE

Journal of Applied Polymer Science Pub Date : 2024-09-23 DOI:10.1002/app.56250

Elí Emanuel Esparza-Flores, Plinho F. Hertz, Rafael C. Rodrigues

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Abstract

The chitosan-genipin complex has been extensively studied and applied in various fields, attracting increasing attention due to its unique characteristics and properties. This complex enables the development of novel materials for applications in biomedical engineering, biotechnology, and medicine. Chitosan is a natural biopolymer, and genipin is an extract obtained from some fruits, mainly from genipap and gardenia; both have demonstrated biodegradability, biocompatibility, and antimicrobial properties. Due to their versatile and reinforced structure, new materials have shown potential use in drug delivery, tissue engineering, scaffolds, curatives, food packaging, and enzyme immobilization. This review will discuss the chitosan and its modifications, the genipin and its reactivity, and finally, the complex chitosan-genipin, showing some recent developments and applications and some prospectives for other applications in new fields, especially as support for enzyme immobilization.

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壳聚糖-基因蛋白复合物在生物技术应用方面的进展和潜力：综述

壳聚糖-基因蛋白复合物已被广泛研究并应用于各个领域，因其独特的特征和性能而日益受到关注。这种复合物可以开发新型材料，应用于生物医学工程、生物技术和医学领域。壳聚糖是一种天然生物聚合物，吉尼平是从一些水果（主要是吉尼帕和栀子）中提取的提取物；两者都具有生物降解性、生物相容性和抗菌性。由于甲壳素具有多功能性和强化结构，这种新材料在药物输送、组织工程、支架、治疗剂、食品包装和酶固定化等方面具有潜在用途。本综述将讨论壳聚糖及其改性、基因素及其反应性，最后是壳聚糖-基因素复合物，展示一些最新的发展和应用，以及在新领域的其他应用前景，特别是作为酶固定的支持物。

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来源期刊

Journal of Applied Polymer Science 化学-高分子科学

CiteScore

5.70

自引率

10.00%

发文量

1280

审稿时长

2.7 months

期刊介绍： The Journal of Applied Polymer Science is the largest peer-reviewed publication in polymers, #3 by total citations, and features results with real-world impact on membranes, polysaccharides, and much more.