The role and mechanism of extracellular traps in chronic rhinosinusitis

IF 6.9 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Biomedicine & Pharmacotherapy Pub Date : 2024-10-31 DOI:10.1016/j.biopha.2024.117655

Jiani Li , He Zhao , Jing Yang , Meng Wang , Zhiwei Cao , Yunxiu Wang , Zhaowei Gu

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Abstract

Chronic rhinosinusitis (CRS) is a common inflammatory disease of the nose that affects millions of individuals worldwide. Recent research has introduced the concept of an immunologic endotype based on the pathological characteristics of CRS and the types of inflammatory cell infiltration. This endotype concept is conducive to understanding CRS pathology and guiding further targeted therapy. Eosinophils and neutrophils infiltrate different proportions in different CRS endotypes and release extracellular traps (ETs) as a response to the extracellular immune response. The mechanisms of formation and biological roles of ETs are complex. ETs can trap extracellular microorganisms and limit the range of inflammation to some extent; however, excessive and long-term ETs may be related to disease severity. This review summarises and explores the mechanism of ETs and the advances in CRS research and proposes new insights into the interaction between ETs and programmed cell death (including autophagy, pyroptosis, and necroptosis) in CRS, providing new ideas for the targeted therapy of CRS.

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细胞外捕获器在慢性鼻炎中的作用和机制

慢性鼻炎（CRS）是一种常见的鼻部炎症性疾病，影响着全球数百万人。最近的研究根据 CRS 的病理特征和炎症细胞浸润类型提出了免疫学内型的概念。这种内型概念有助于了解 CRS 的病理，并指导进一步的靶向治疗。在不同的 CRS 内型中，嗜酸性粒细胞和中性粒细胞的浸润比例不同，并释放出细胞外捕获物（ETs）作为对细胞外免疫反应的反应。ETs 的形成机制和生物学作用十分复杂。ETs 可以捕获细胞外微生物，并在一定程度上限制炎症范围；然而，过量和长期的 ETs 可能与疾病的严重程度有关。本综述总结和探讨了ETs的机制和CRS研究的进展，并对CRS中ETs与程序性细胞死亡（包括自噬、热噬和坏死）之间的相互作用提出了新的见解，为CRS的靶向治疗提供了新思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomedicine & Pharmacotherapy 医学-药学

CiteScore

11.90

自引率

2.70%

发文量

1621

审稿时长

48 days

期刊介绍： Biomedicine & Pharmacotherapy stands as a multidisciplinary journal, presenting a spectrum of original research reports, reviews, and communications in the realms of clinical and basic medicine, as well as pharmacology. The journal spans various fields, including Cancer, Nutriceutics, Neurodegenerative, Cardiac, and Infectious Diseases.