Effect of Raha syrup on the motivational effects of morphine and CSF serotonin levels in rats

IF 1.7 4区心理学 Q3 PSYCHOLOGY, BIOLOGICAL

Learning and Motivation Pub Date : 2024-11-01 DOI:10.1016/j.lmot.2024.102063

Mitra As’habi , Mahdi Zahedi-Khorasani , Freshteh Haerifar , Ali Ghanbari , Ali khaleghian , Hossein Miladi-Gorji

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引用次数: 0

Abstract

Opiates may influence motivational processes by a dysregulation of brain reward pathways that play a role in context-induced reinstatement of drug seeking. Raha syrup as herbal bioactive compounds with anti-anxiety/depressant effects may be prevented morphine-induced reward and motivation effects. Therefore, the aim of this study was to investigate the effect of Raha syrup on the rewarding effects of morphine and motivational aspects of morphine-seeking behavior in morphine-induced conditioned place preference (CPP) model and also the cerebrospinal fluid (CSF) serotonin levels following the extinction and reinstatement in rats. In this study, adult male Wistar rats received Raha syrup via oral gavage to assess of the acquisition, extinction and reinstatement of the morphine-induced CPP and as well as measurement of the CSF serotonin levels. Administration of Raha syrup during the conditioning period significantly attenuated the acquisition of morphine-induced CPP, and increased the CSF serotonin level, 6 days after cessation of treatment during extinction, while did not affect the duration of the extinction period. Also, Raha syrup during the extinction period did not affect the reinstatement of morphine-induced CPP and the CSF serotonin levels in rats. We conclude that Raha syrup attenuated the acquisition of morphine reward probably through an increase in CSF serotonin, while could not maintain the extinguished CPP and had no effect on the reinstatement. Therefore, Raha syrup as a useful adjunctive therapeutic strategy may exert a protective effect against opiate-related rewards, while it may be ineffective to prevention of motivation or drug-seeking reinstatement (relapse).

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拉哈糖浆对大鼠吗啡动机效应和脑脊液血清素水平的影响

鸦片制剂可能会通过大脑奖赏通路的失调来影响动机过程，而大脑奖赏通路在情境诱导的药物寻求恢复中发挥着作用。拉哈糖浆作为具有抗焦虑/抑郁作用的草药生物活性化合物，可能会防止吗啡引起的奖赏和动机效应。因此，本研究旨在探讨拉哈糖浆对吗啡诱导的条件性位置偏好（CPP）模型中吗啡的奖赏效应和吗啡寻求行为动机方面的影响，以及对大鼠绝迹和恢复后脑脊液（CSF）中血清素水平的影响。在这项研究中，成年雄性 Wistar 大鼠通过口服 Raha 糖浆来评估吗啡诱导的条件性位置偏好模型的获得、消退和恢复，以及 CSF 血清素水平的测量。在条件反射期服用拉哈糖浆可明显减弱吗啡诱导的CPP的获得，并在消退期停止治疗6天后增加脑脊液血清素水平，但不影响消退期的持续时间。此外，在消退期服用拉哈糖浆也不会影响吗啡诱导的CPP的恢复和大鼠脑脊液血清素水平。我们的结论是，拉哈糖浆可能通过增加脑脊液血清素来减少吗啡奖赏的获得，但不能维持已熄灭的CPP，对恢复也没有影响。因此，拉哈糖浆作为一种有用的辅助治疗策略，可能会对鸦片相关奖赏产生保护作用，但对预防动机或觅药复吸（复发）可能无效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Learning and Motivation Multiple-

CiteScore

2.90

自引率

0.00%

发文量

期刊介绍： Learning and Motivation features original experimental research devoted to the analysis of basic phenomena and mechanisms of learning, memory, and motivation. These studies, involving either animal or human subjects, examine behavioral, biological, and evolutionary influences on the learning and motivation processes, and often report on an integrated series of experiments that advance knowledge in this field. Theoretical papers and shorter reports are also considered.