The QT interval in Parkinson's disease: a systematic review.

IF 1.8 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Geriatric Cardiology Pub Date : 2024-09-28 DOI:10.26599/1671-5411.2024.09.003

Simon W Rabkin

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引用次数: 0

Abstract

Background: PD (PD) is associated with a twofold increase in the risk of death especially sudden death. A predisposing factor for cardiac sudden death is prolongation of the QT interval. This study evaluated the potential association between QT interval and PD.

Methods: A systematic search was conducted of Medline and EMBASE using the search terms "PD" AND "QT interval" OR "Cardiac Repolarization" to identify articles.

Results: Seven studies with persons with PD (n = 981) and control groups were identified. There was a significant difference in QT interval comparing patients with PD and persons without PD. The odds ratio showed a significant (P < 0.001) 2.6-fold (random effect) greater QTc prolongation in PD compared to control. Overall, there was a significantly longer QT in patients with PD than controls of 10.7 ± 2.8 ms. Data analysis did not show much publication bias. Focusing only on studies that related the QT interval to the severity of PD as assessed by Hoehn-Yahr classification (n = 6), there was a significant (P = 0.004) overall correlation between QT interval and the severity of PD. There was little publication bias. The data directly examining patients with PD taking any drug than might prolong QT do not support an association between these mediations and QT prolongation.

Conclusion: Individuals with PD have a longer QT interval than individuals without PD. The QT interval is associated with a greater severity of PD and a greater probability of developing more severe PD. The QT interval should be considered in assessment of PD and possibly as a target for the treatment of PD.

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帕金森病的 QT 间期：系统综述。

背景：先天性心脏病（PD）导致死亡风险增加两倍，尤其是猝死。心脏性猝死的一个诱发因素是 QT 间期延长。本研究评估了 QT 间期与 PD 之间的潜在关联：方法：使用 "PD "和 "QT间期 "或 "心脏复极 "等检索词对Medline和EMBASE进行系统检索，以确定相关文章：结果：共发现七项研究，研究对象包括帕金森病患者（n = 981）和对照组。与非帕金森病患者相比，帕金森病患者的 QT 间期存在明显差异。几率比显示，与对照组相比，帕金森病患者的 QTc 延长明显（P < 0.001）高出 2.6 倍（随机效应）。总体而言，与对照组相比，帕金森病患者的QT明显延长（10.7 ± 2.8 ms）。数据分析未显示太多发表偏倚。仅关注将 QT 间期与按 Hoehn-Yahr 分级评估的帕金森病严重程度相关的研究（n = 6），QT 间期与帕金森病严重程度之间存在显著相关性（P = 0.004）。几乎不存在发表偏倚。直接研究服用任何可能延长QT的药物的帕金森病患者的数据并不支持这些介质与QT延长之间的关联：结论：与非帕金森病患者相比，帕金森病患者的 QT 间期更长。QT间期与帕金森病的严重程度和发展为更严重帕金森病的可能性有关。在评估脊髓灰质炎时应考虑 QT 间期，并可能将其作为治疗脊髓灰质炎的目标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Geriatric Cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-GERIATRICS & GERONTOLOGY

CiteScore

3.30

自引率

4.00%

发文量

1161

期刊介绍： JGC focuses on both basic research and clinical practice to the diagnosis and treatment of cardiovascular disease in the aged people, especially those with concomitant disease of other major organ-systems, such as the lungs, the kidneys, liver, central nervous system, gastrointestinal tract or endocrinology, etc.