The Association between Fatty Liver Index and Lower Limb Arterial Calcification in Patients with Type 2 Diabetes Mellitus.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-10-10 eCollection Date: 2024-10-01 DOI:10.31083/j.rcm2510362

Peibiao Mai, Qilong Li, Sijin Li, Chunhong Wang, Shuwan Xu, Kun Zhang, Niansang Luo

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引用次数: 0

Abstract

Background: Peripheral arterial calcification is a prevalent condition in patients with type 2 diabetes mellitus (T2DM), resulting in lower-limb amputation and reduced life quality. Non-alcoholic fatty liver disease (NAFLD), which can be simply evaluated using the fatty liver index (FLI), is closely associated with T2DM development. In this study, we aimed to explore the relationship between FLI and lower limb arterial calcification (LLAC) in T2DM patients and to reveal the value of T2DM patients with NAFLD in predicting the occurrence of LLAC.

Methods: A total of 77 T2DM patients with LLAC who underwent comprehensive physical and health examinations, serological examinations, as well as lower limb computed tomography imaging at Sun Yat-sen Memorial Hospital of Sun Yat-sen University between January 2018 and January 2019 were enrolled in this study. The FLI was calculated using body mass index, waist circumference, triglycerides, and γ-glutamyl transferase. Additionally, LLAC was evaluated using computed tomography with the Agatston scoring algorithm. The patients were divided into three groups based on their FLI values: Non-liver disease group (FLI <30, n = 29), borderline-liver disease group (30 ≤ FLI < 60, n = 32), and NAFLD group (FLI ≥60, n = 16). Univariate and multivariate binary logistic regression analyses were employed to investigate the association between FLI and LLAC in T2DM patients. Furthermore, differences in LLAC among groups were analyzed using post-hoc multiple comparisons and ordinal logistic regression model analysis.

Results: Univariate and multivariate analyses showed that age and FLI influenced LLAC severity in T2DM patients. Moreover, T2DM patients in the NAFLD group had significantly lower LLAC scores than those in the Non-liver disease group. The correlation analysis showed that FLI was negatively associated with LLAC scores (R = -0.31, p = 0.006), while age was positively associated (R = 0.361, p = 0.001).

Conclusions: Our study revealed an inverse relationship between FLI and the degree of LLAC. This indicates that, based on evidence in the current research, NAFLD may not be reliable as a predictor of LLAC in T2DM patients.

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2 型糖尿病患者脂肪肝指数与下肢动脉钙化之间的关系

背景：外周动脉钙化是 2 型糖尿病（T2DM）患者的常见病，可导致下肢截肢和生活质量下降。非酒精性脂肪肝（NAFLD）可通过脂肪肝指数（FLI）进行简单评估，它与 T2DM 的发展密切相关。本研究旨在探讨非酒精性脂肪肝与 T2DM 患者下肢动脉钙化（LLAC）之间的关系，并揭示非酒精性脂肪肝 T2DM 患者在预测 LLAC 发生方面的价值：本研究共纳入2018年1月至2019年1月期间在中山大学孙逸仙纪念医院接受全面身体健康检查、血清学检查以及下肢计算机断层扫描成像的77例T2DM合并LLAC患者。使用体重指数、腰围、甘油三酯和γ-谷氨酰转移酶计算FLI。此外，还使用计算机断层扫描和 Agatston 评分算法对 LLAC 进行了评估。根据患者的 FLI 值将其分为三组：非肝脏疾病组（FLI 结果：非肝脏疾病组）；肝脏疾病组（FLI 结果：非肝脏疾病组）：单变量和多变量分析表明，年龄和 FLI 对 T2DM 患者的 LLAC 严重程度有影响。此外，非酒精性脂肪肝组 T2DM 患者的 LLAC 评分明显低于非肝病组。相关性分析表明，FLI 与 LLAC 评分呈负相关（R = -0.31，p = 0.006），而年龄与 LLAC 评分呈正相关（R = 0.361，p = 0.001）：我们的研究表明，FLI 与 LLAC 的程度呈反比关系。结论：我们的研究显示，FLI 与 LLAC 程度之间存在反向关系，这表明根据目前的研究证据，非酒精性脂肪肝作为 T2DM 患者 LLAC 的预测因子可能并不可靠。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.