Association among raised intraventricular pressure, clinical signs, and magnetic resonance imaging findings in dogs with congenital internal hydrocephalus.
Daniela Farke, Agnieszka Olszewska, Kathrin Büttner, Martin J Schmidt
{"title":"Association among raised intraventricular pressure, clinical signs, and magnetic resonance imaging findings in dogs with congenital internal hydrocephalus.","authors":"Daniela Farke, Agnieszka Olszewska, Kathrin Büttner, Martin J Schmidt","doi":"10.1111/jvim.17235","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Dogs with internal hydrocephalus do not necessarily have high intraventricular pressure (IVP).</p><p><strong>Hypothesis/objectives: </strong>Not all reported MRI findings indicate high IVP and some clinical signs might be associated with elevated IVP and syringomyelia.</p><p><strong>Animals: </strong>Fifty-three dogs.</p><p><strong>Materials and methods: </strong>Cross-sectional study. Clinical signs and MRI findings were evaluated for an association of IVP >12 mm Hg and syringomyelia.</p><p><strong>Results: </strong>High IVP was associated with obtundation OR 4.64 (95% CI 1.27-16.93) (P = .02), head tilt OR 6.42 (95% CI 1.08-37.97) (P = .04) and nystagmus OR 8.24 (95% CI 1.44-47.07) (P = .02). Pain was associated with syringomyelia OR 3.4 (95% CI 0.98-11.78) (P = .05). The number of affected ventricles was associated with high IVP OR 2.85 (95% CI 0.97-8.33) (P = .05) and syringomyelia OR 12.74 (95% CI 2.93-55.4) (P = .0007). Periventricular edema OR 24.46 (95% CI 4.54-131.77), OR 7.61 (95% CI 1.91-30.32) (P < .0002, P = .004) and signal void sign OR 17.34 (95% CI 4.01-74.95), OR 4.18 (95% CI 1.16-15.02) (P < .0001, P = .03) were associated with high IVP and syringomyelia. The probability for syringomyelia is lower with disruption of the internal capsule OR 0.19 (95% CI 0.05-0.72) (P = .01) and higher VBR OR 0.25 (95% CI 0.1-0.63) (P = .004).</p><p><strong>Conclusions and clinical importance: </strong>Previously reported MRI findings are not predictive of high IVP. Clinical signs and MRI findings should be used to make a diagnosis of internal hydrocephalus in dogs with or without high IVP.</p>","PeriodicalId":17462,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":" ","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Veterinary Internal Medicine","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1111/jvim.17235","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Background: Dogs with internal hydrocephalus do not necessarily have high intraventricular pressure (IVP).
Hypothesis/objectives: Not all reported MRI findings indicate high IVP and some clinical signs might be associated with elevated IVP and syringomyelia.
Animals: Fifty-three dogs.
Materials and methods: Cross-sectional study. Clinical signs and MRI findings were evaluated for an association of IVP >12 mm Hg and syringomyelia.
Results: High IVP was associated with obtundation OR 4.64 (95% CI 1.27-16.93) (P = .02), head tilt OR 6.42 (95% CI 1.08-37.97) (P = .04) and nystagmus OR 8.24 (95% CI 1.44-47.07) (P = .02). Pain was associated with syringomyelia OR 3.4 (95% CI 0.98-11.78) (P = .05). The number of affected ventricles was associated with high IVP OR 2.85 (95% CI 0.97-8.33) (P = .05) and syringomyelia OR 12.74 (95% CI 2.93-55.4) (P = .0007). Periventricular edema OR 24.46 (95% CI 4.54-131.77), OR 7.61 (95% CI 1.91-30.32) (P < .0002, P = .004) and signal void sign OR 17.34 (95% CI 4.01-74.95), OR 4.18 (95% CI 1.16-15.02) (P < .0001, P = .03) were associated with high IVP and syringomyelia. The probability for syringomyelia is lower with disruption of the internal capsule OR 0.19 (95% CI 0.05-0.72) (P = .01) and higher VBR OR 0.25 (95% CI 0.1-0.63) (P = .004).
Conclusions and clinical importance: Previously reported MRI findings are not predictive of high IVP. Clinical signs and MRI findings should be used to make a diagnosis of internal hydrocephalus in dogs with or without high IVP.
背景:患有内脑积水的狗并不一定具有高脑室内压(IVP):并非所有报告的 MRI 结果都表明 IVP 偏高,一些临床症状可能与 IVP 升高和鞘膜积液有关:材料和方法:横断面研究:横断面研究。对临床症状和磁共振成像结果进行评估,以确定 IVP >12 mm Hg 与鞘膜积液是否相关:高 IVP 与昏迷 OR 4.64 (95% CI 1.27-16.93) (P = .02)、头部倾斜 OR 6.42 (95% CI 1.08-37.97) (P = .04) 和眼球震颤 OR 8.24 (95% CI 1.44-47.07) (P = .02) 相关。疼痛与鞘膜积液 OR 3.4 (95% CI 0.98-11.78) (P = .05) 相关。受影响脑室的数量与高 IVP OR 2.85 (95% CI 0.97-8.33) (P = .05) 和鞘膜积液 OR 12.74 (95% CI 2.93-55.4) (P = .0007) 相关。脑室周围水肿 OR 24.46(95% CI 4.54-131.77),OR 7.61(95% CI 1.91-30.32)(P 结论和临床重要性:之前报道的磁共振成像结果不能预测高IVP。临床症状和 MRI 检查结果应用于诊断有或没有高 IVP 的犬的内脑积水。
期刊介绍:
The mission of the Journal of Veterinary Internal Medicine is to advance veterinary medical knowledge and improve the lives of animals by publication of authoritative scientific articles of animal diseases.