A randomized controlled trial comparing carbazochrome sodium sulfonate and tranexamic acid in reducing blood loss and inflammatory response after simultaneous bilateral total hip arthroplasty.

IF 1.6 4区 医学
Guangtao Han, Lijun Cai, Qin Wang, Qianhao Li, Pengde Kang
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引用次数: 0

Abstract

Purpose: A drug known as carbazochrome sodium sulfonate (CSS) can reduce blood loss. But, it is not known how it can prevent the development of hemostatic and inflammatory conditions in patients who undergo bilateral simultaneous total hip arthroplasty (SBTHA). This study will analyze the safety and effectiveness of combining this drug with SBTHA.

Methods: The study was conducted on 100 patients who underwent SBTHA with simultaneous total hip replacement. They were split into two groups: group B received TXA with CSS, group A received TXA with no CSS. The main observation of the study was the total blood loss, which is the most common indication of blood loss. Other secondary indicators of the study included hidden blood loss, postoperative blood transfusion rate, level of inflammatory reactants, hip function, pain score, venous thromboembolism (VTE) and the incidence of adverse events.

Results: Group B had significantly lower TBL and HBL compared to Group A. Group B showed significant improvement in inflammatory biomarker levels, blood transfusion rate when compared to Group A (p < .05). No thromboembolic complications occurred in either group. There were no significant differences between the two groups in terms of postoperative swelling rate, intraoperative blood loss, visual analog scale pain score, platelet count, discharge motion and average length of stay.

Conclusions: As a hemostatic agent, CSS combined with TXA can reduce postoperative blood loss in patients undergoing SBTHA, and is more effective than TXA alone in terms of blood loss and inflammation, and does not increase the incidence of thromboembolic complications.

一项随机对照试验,比较卡巴克酸钠磺酸盐和氨甲环酸在同时进行双侧全髋关节置换术后减少失血和炎症反应的效果。
目的:一种名为卡巴肼磺酸钠(CSS)的药物可以减少失血量。但它如何防止双侧同时全髋关节置换术(SBTHA)患者出现止血和炎症情况尚不清楚。本研究将分析将该药物与 SBTHA 结合使用的安全性和有效性:研究对象为 100 名接受 SBTHA 和同期全髋关节置换术的患者。他们被分为两组:B 组接受含 CSS 的 TXA,A 组接受不含 CSS 的 TXA。研究的主要观察指标是总失血量,这是最常见的失血指标。其他次要指标包括隐性失血、术后输血率、炎症反应物水平、髋关节功能、疼痛评分、静脉血栓栓塞(VTE)和不良事件的发生率:与 A 组相比,B 组的 TBL 和 HBL 明显降低;与 A 组相比,B 组的炎症生物标志物水平和输血率明显改善(P < .05)。两组均未发生血栓栓塞并发症。两组在术后肿胀率、术中失血量、视觉模拟量表疼痛评分、血小板计数、出院动作和平均住院时间方面无明显差异:作为一种止血剂,CSS 联合 TXA 可以减少 SBTHA 患者的术后失血量,在减少失血和炎症方面比单独使用 TXA 更有效,并且不会增加血栓栓塞并发症的发生率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
自引率
0.00%
发文量
91
期刊介绍: Journal of Orthopaedic Surgery is an open access peer-reviewed journal publishing original reviews and research articles on all aspects of orthopaedic surgery. It is the official journal of the Asia Pacific Orthopaedic Association. The journal welcomes and will publish materials of a diverse nature, from basic science research to clinical trials and surgical techniques. The journal encourages contributions from all parts of the world, but special emphasis is given to research of particular relevance to the Asia Pacific region.
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