Multiple strategies enhance the efficacy of MSC-Exos transplantation for spinal cord injury

IF 4.6 2区医学 Q1 NEUROSCIENCES

Experimental Neurology Pub Date : 2024-10-29 DOI:10.1016/j.expneurol.2024.115038

Yan Xu , Xuesong Wang , Xiaolei Zhou , Wenhui Zeng , Jiayi Yuan , Junsong Ye

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引用次数: 0

Abstract

Spinal cord injury (SCI) is a relatively common and lethal dangerous disease of the central nervous system, for which there is a lack of effective clinical treatments. It has been found that mesenchymal stem cell-derived exosomes (MSC-Exos) play a key role in alleviating SCI through mechanisms such as regulating the microenvironment, promoting angiogenesis, and facilitating axonal regeneration. However, the drawbacks of natural exosomes, such as low yield, weak activity, and low targeting ability, limit their clinical applications. In recent years, MSCs-Exos have gradually become a research hotspot for treating SCI through miRNA modulation, combined hydrogel, and preculture. In addition, exosomes as good biocompatible drugs, nucleic acid, and other delivery carriers have shown a broad application prospect in treating SCI. This article summarizes the pathogenesis of SCI and the research progress of MSC-Exos in the treatment of SCI in recent years, and provides a systematic review of the mechanisms of MSC exosomes and their combination with different modalities in the treatment of SCI.

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多种策略提高了间充质干细胞-Exos 移植治疗脊髓损伤的疗效。

脊髓损伤（SCI）是中枢神经系统中一种较为常见的致命性危险疾病，目前尚缺乏有效的临床治疗方法。研究发现，间充质干细胞衍生的外泌体（MSC-Exos）通过调节微环境、促进血管生成和促进轴突再生等机制，在缓解脊髓损伤方面发挥着关键作用。然而，天然外泌体存在产量低、活性弱、靶向能力差等缺点，限制了其临床应用。近年来，间充质干细胞外泌体通过调控 miRNA、联合水凝胶、预培养等方法逐渐成为治疗 SCI 的研究热点。此外，外泌体作为良好的生物相容性药物、核酸等递送载体，在治疗SCI方面也显示出广阔的应用前景。本文总结了SCI的发病机理以及近年来间充质干细胞外泌体治疗SCI的研究进展，并对间充质干细胞外泌体及其与不同方式结合治疗SCI的机制进行了系统综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Experimental Neurology 医学-神经科学

CiteScore

10.10

自引率

3.80%

发文量

258

审稿时长

42 days

期刊介绍： Experimental Neurology, a Journal of Neuroscience Research, publishes original research in neuroscience with a particular emphasis on novel findings in neural development, regeneration, plasticity and transplantation. The journal has focused on research concerning basic mechanisms underlying neurological disorders.