Genome-wide Association Studies of Diabetic Kidney Disease in East Asians With Type 2 Diabetes: Achievements and Future Perspectives.

IF 3.5 4区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Current medicinal chemistry Pub Date : 2024-10-31 DOI:10.2174/0109298673328801241015165257

Binura Taurbekova, Kymbat Mukhtarova, Zhandos Salpynov, Joseph Almazan, Kuralay Atageldiyeva, Antonio Sarria-Santamera

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Abstract

Diabetic kidney disease is a devastating diabetic complication, affecting up to half of people suffering from diabetes. The global burden of diabetic kidney disease is steadily increasing worldwide along with the growing prevalence of type 2 diabetes. The epidemic rise of type 2 diabetes is primarily observed in Asia, including the East Asian regions. It is generally accepted that heredity is one of the main determinants in the pathogenesis of diabetic kidney disease. Since the advent of genome-wide association studies, numerous studies have been published to identify the genetic loci susceptible to diabetic kidney disease among diverse populations. Although genome-wide association studies exploring diabetic kidney disease susceptibility loci have focused primarily on populations of European descent, a number of novel genetic variants associated with diabetic kidney disease have also been successfully revealed among East Asians. A comprehensive analysis of the genetic architecture and pathophysiological pathways of diabetic kidney disease may allow the identification of new potential therapeutic targets. This review aimed to summarize genome-wide association studies examining genetic variants associated with diabetic kidney disease in the populations of East Asian ancestry with type 2 diabetes and presented our perspective on the future of this field.

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东亚 2 型糖尿病患者糖尿病肾病的全基因组关联研究：成就与未来展望》。

糖尿病肾病是一种破坏性的糖尿病并发症，多达一半的糖尿病患者会受到影响。随着 2 型糖尿病患病率的不断上升，糖尿病肾病给全球带来的负担也在稳步加重。2 型糖尿病的流行主要发生在亚洲，包括东亚地区。人们普遍认为，遗传是糖尿病肾病发病机制的主要决定因素之一。自全基因组关联研究问世以来，已有大量研究发表，以确定不同人群中易患糖尿病肾病的基因位点。尽管探索糖尿病肾病易感基因位点的全基因组关联研究主要集中在欧洲后裔人群中，但在东亚人中也成功发现了一些与糖尿病肾病相关的新型基因变异。对糖尿病肾病的遗传结构和病理生理途径进行全面分析，有助于确定新的潜在治疗靶点。本综述旨在总结在东亚血统的2型糖尿病患者中开展的与糖尿病肾病相关的全基因组关联研究，并展望这一领域的未来。

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来源期刊

Current medicinal chemistry 医学-生化与分子生物学

CiteScore

8.60

自引率

2.40%

发文量

468

审稿时长

3 months

期刊介绍： Aims & Scope Current Medicinal Chemistry covers all the latest and outstanding developments in medicinal chemistry and rational drug design. Each issue contains a series of timely in-depth reviews and guest edited thematic issues written by leaders in the field covering a range of the current topics in medicinal chemistry. The journal also publishes reviews on recent patents. Current Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments.