18F-FDG PET/CT for predicting inferior vena cava wall invasion in patients of renal cell carcinoma with the presence of inferior vena cava tumor thrombus.

IF 2.9 3区 医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Anhui Zhu, Xiaoyan Hou, Na Guo, Weifang Zhang
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引用次数: 0

Abstract

Introduction: Preoperative evaluation of inferior vena cava (IVC) wall invasion is very important to improve outcomes of patients with renal cell carcinoma (RCC), and may allow surgical urologists to treat the IVC more effectively. The objective of this study was to evaluate preoperative 18F-FDG PET/CT in patients with RCC and IVC tumor thrombus (IVCTT) for the diagnosis of IVC wall invasion.

Methods: This retrospective case-control study evaluated 68 patients with RCC with level I-IV tumor thrombus. According to the histopathologic examination result, the patients were divided into IVC wall invasion group and non-invasion group. The 18F-FDG PET/CT features between two groups were analyzed. Furthermore, a logistic regression model was used to determine if there was an association between PET/CT features and IVC wall invasion.

Results: Sixty-eight patients were evaluated, and 55.9% (38/68) had IVC wall invasion. Compared with non-invasion group, invasion group had higher SUVmax of RCC, higher SURmax (tumor to tumor thrombus ratio, Tu/Th), higher IVCTT coronal diameter, and longer IVCTT craniocaudal extent (all p < 0.05). Multivariate analysis showed that SURmax (Tu/Th) (OR 8.760 [95%CI, 1.019-75.310]; p = 0.048) and the maximum coronal diameter of IVCTT (OR 1.143 [95%CI, 1.029-1.269]; p = 0.028) were predictors of IVC wall invasion. A model combining SURmax (Tu/Th) and the maximum coronal diameter of IVCTT achieved an AUC of 0.855 (95%CI, 0.757-0.954). The specificity and sensitivity for assessing IVC wall invasion was 92.1% and 76.7%, respectively.

Conclusions: Increases in SURmax (Tu/Th) and the maximum coronal diameter of IVCTT are associated with a higher probability of IVC wall invasion. Preoperative 18F-FDG PET/CT imaging may be used to assess IVC wall invasion.

18F-FDG PET/CT 用于预测存在下腔静脉肿瘤血栓的肾细胞癌患者的下腔静脉壁侵犯。
导言:下腔静脉(IVC)壁侵犯的术前评估对改善肾细胞癌(RCC)患者的预后非常重要,可使泌尿外科医生更有效地治疗IVC。本研究的目的是评估RCC患者术前18F-FDG PET/CT和IVC肿瘤血栓(IVCTT)对IVC壁侵犯诊断的影响:这项回顾性病例对照研究评估了68例有I-IV级肿瘤血栓的RCC患者。根据组织病理学检查结果,将患者分为 IVC 壁侵犯组和非侵犯组。分析了两组患者的 18F-FDG PET/CT 特征。此外,还使用逻辑回归模型确定 PET/CT 特征与 IVC 壁侵犯之间是否存在关联:结果:68 名患者接受了评估,55.9%(38/68)的患者有 IVC 壁侵犯。与非侵犯组相比,侵犯组的RCC SUVmax更高、SURmax(肿瘤与肿瘤血栓比值,Tu/Th)更高、IVCTT冠状径更高以及IVCTT头尾范围更长(均为P 结论:SURmax(肿瘤与肿瘤血栓比值,Tu/Th)的升高与IVCTT头尾范围的延长有关:SURmax(Tu/Th)和IVCTT冠状面最大直径的增加与更高的静脉壁侵犯概率相关。术前 18F-FDG PET/CT 成像可用于评估 IVC 壁侵犯。
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来源期刊
BMC Medical Imaging
BMC Medical Imaging RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
4.60
自引率
3.70%
发文量
198
审稿时长
27 weeks
期刊介绍: BMC Medical Imaging is an open access journal publishing original peer-reviewed research articles in the development, evaluation, and use of imaging techniques and image processing tools to diagnose and manage disease.
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