A cross-species foundation model for single cells

IF 2.9 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemistry Biochemistry Pub Date : 2024-10-31 DOI:10.1038/s41422-024-01045-9

Korbinian Traeuble, Matthias Heinig

引用次数: 0

Abstract

Foundation models in transcriptomics have gained attention due to their ability to generalize across tasks with limited labeled data. GeneCompass builds upon these models by incorporating prior biological knowledge and datasets from both human and mouse cells, enhancing its capacity for cross-species analysis and advancing the field of single-cell transcriptomics.

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单细胞的跨物种基础模型

转录组学中的基础模型因其在有限标记数据的任务中的通用能力而备受关注。GeneCompass 在这些模型的基础上，结合了先前的生物学知识以及人类和小鼠细胞的数据集，增强了跨物种分析能力，推动了单细胞转录组学领域的发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochemistry Biochemistry 生物-生化与分子生物学

CiteScore

5.50

自引率

3.40%

发文量

336

审稿时长

1-2 weeks

期刊介绍： Biochemistry provides an international forum for publishing exceptional, rigorous, high-impact research across all of biological chemistry. This broad scope includes studies on the chemical, physical, mechanistic, and/or structural basis of biological or cell function, and encompasses the fields of chemical biology, synthetic biology, disease biology, cell biology, nucleic acid biology, neuroscience, structural biology, and biophysics. In addition to traditional Research Articles, Biochemistry also publishes Communications, Viewpoints, and Perspectives, as well as From the Bench articles that report new methods of particular interest to the biological chemistry community.