A cross-species foundation model for single cells

IF 28.1 1区生物学 Q1 CELL BIOLOGY

Cell Research Pub Date : 2024-10-31 DOI:10.1038/s41422-024-01045-9

Korbinian Traeuble, Matthias Heinig

引用次数: 0

Abstract

Foundation models in transcriptomics have gained attention due to their ability to generalize across tasks with limited labeled data. GeneCompass builds upon these models by incorporating prior biological knowledge and datasets from both human and mouse cells, enhancing its capacity for cross-species analysis and advancing the field of single-cell transcriptomics.

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单细胞的跨物种基础模型

转录组学中的基础模型因其在有限标记数据的任务中的通用能力而备受关注。GeneCompass 在这些模型的基础上，结合了先前的生物学知识以及人类和小鼠细胞的数据集，增强了跨物种分析能力，推动了单细胞转录组学领域的发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Research 生物-细胞生物学

CiteScore

53.90

自引率

0.70%

发文量

2420

审稿时长

2.3 months

期刊介绍： Cell Research (CR) is an international journal published by Springer Nature in partnership with the Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences (CAS). It focuses on publishing original research articles and reviews in various areas of life sciences, particularly those related to molecular and cell biology. The journal covers a broad range of topics including cell growth, differentiation, and apoptosis; signal transduction; stem cell biology and development; chromatin, epigenetics, and transcription; RNA biology; structural and molecular biology; cancer biology and metabolism; immunity and molecular pathogenesis; molecular and cellular neuroscience; plant molecular and cell biology; and omics, system biology, and synthetic biology. CR is recognized as China's best international journal in life sciences and is part of Springer Nature's prestigious family of Molecular Cell Biology journals.