A narrative review on lung injury: mechanisms, biomarkers, and monitoring

IF 8.8 1区医学 Q1 CRITICAL CARE MEDICINE

Critical Care Pub Date : 2024-10-31 DOI:10.1186/s13054-024-05149-x

Wenping Fan, Biyu Gui, Xiaolei Zhou, Li Li, Huaiyong Chen

引用次数: 0

Abstract

Lung injury is closely associated with the heterogeneity, severity, mortality, and prognosis of various respiratory diseases. Effective monitoring of lung injury is crucial for the optimal management and improved outcomes of patients with lung diseases. This review describes acute and chronic respiratory diseases characterized by significant lung injury and current clinical tools for assessing lung health. Furthermore, we summarized the mechanisms of lung cell death observed in these diseases and highlighted recently identified biomarkers in the plasma indicative of injury to specific cell types and scaffold structure in the lung. Last, we propose an artificial intelligence-driven lung injury monitoring model to assess disease severity, and predict mortality and prognosis, aiming to achieve precision and personalized medicine.

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肺损伤综述：机制、生物标志物和监测

肺损伤与各种呼吸系统疾病的异质性、严重程度、死亡率和预后密切相关。有效监测肺损伤对于肺部疾病患者的优化管理和改善预后至关重要。本综述介绍了以严重肺损伤为特征的急性和慢性呼吸系统疾病，以及目前评估肺健康的临床工具。此外，我们还总结了在这些疾病中观察到的肺细胞死亡机制，并强调了最近在血浆中发现的表明肺部特定细胞类型和支架结构损伤的生物标志物。最后，我们提出了一种人工智能驱动的肺损伤监测模型，用于评估疾病严重程度、预测死亡率和预后，旨在实现精准和个性化医疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Critical Care 医学-危重病医学

CiteScore

20.60

自引率

3.30%

发文量

348

审稿时长

1.5 months

期刊介绍： Critical Care is an esteemed international medical journal that undergoes a rigorous peer-review process to maintain its high quality standards. Its primary objective is to enhance the healthcare services offered to critically ill patients. To achieve this, the journal focuses on gathering, exchanging, disseminating, and endorsing evidence-based information that is highly relevant to intensivists. By doing so, Critical Care seeks to provide a thorough and inclusive examination of the intensive care field.