Effect of acute exercise in carriers of TBC1D4 mutation

IF 18.9 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Nature metabolism Pub Date : 2024-10-31 DOI:10.1038/s42255-024-01116-6

Leslie J. Baier, Clifton Bogardus

引用次数: 0

Abstract

A nonsense mutation in TBC1D4 has previously been associated with hyperinsulinaemia and increased risk of type 2 diabetes mellitus. A new report shows that carriers have isolated muscle insulin resistance that improves after an acute bout of exercise.

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急性运动对 TBC1D4 基因突变携带者的影响

TBC1D4 的无义突变以前与高胰岛素血症和 2 型糖尿病风险增加有关。一份新的报告显示，携带者的孤立肌肉胰岛素抵抗在急性运动后会得到改善。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

27.50

自引率

2.40%

发文量

170

期刊介绍： Nature Metabolism is a peer-reviewed scientific journal that covers a broad range of topics in metabolism research. It aims to advance the understanding of metabolic and homeostatic processes at a cellular and physiological level. The journal publishes research from various fields, including fundamental cell biology, basic biomedical and translational research, and integrative physiology. It focuses on how cellular metabolism affects cellular function, the physiology and homeostasis of organs and tissues, and the regulation of organismal energy homeostasis. It also investigates the molecular pathophysiology of metabolic diseases such as diabetes and obesity, as well as their treatment. Nature Metabolism follows the standards of other Nature-branded journals, with a dedicated team of professional editors, rigorous peer-review process, high standards of copy-editing and production, swift publication, and editorial independence. The journal has a high impact factor, has a certain influence in the international area, and is deeply concerned and cited by the majority of scholars.