Building the epigenetic fortress with PRC2.2

IF 17.3 1区生物学 Q1 CELL BIOLOGY

Nature Cell Biology Pub Date : 2024-10-31 DOI:10.1038/s41556-024-01551-3

Fides Zenk

引用次数: 0

Abstract

How heterochromatin is established de novo in early embryos is unknown. A study now shows that the sequential recruitment of the key regulator JARID2 recruits PRC2.2 to H2AK119ub and ensures proper H3K27me2/3 deposition. This prevents premature enhancer activation, which is crucial for gene regulation and lineage specification.

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利用 PRC2.2 构建表观遗传堡垒

异染色质是如何在早期胚胎中从头建立的尚不清楚。现在的一项研究表明，关键调控因子JARID2的顺序招募将PRC2.2招募到H2AK119ub，并确保适当的H3K27me2/3沉积。这可以防止增强子过早激活，而增强子激活对基因调控和品系规范至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Cell Biology 生物-细胞生物学

CiteScore

28.40

自引率

0.90%

发文量

219

审稿时长

3 months

期刊介绍： Nature Cell Biology, a prestigious journal, upholds a commitment to publishing papers of the highest quality across all areas of cell biology, with a particular focus on elucidating mechanisms underlying fundamental cell biological processes. The journal's broad scope encompasses various areas of interest, including but not limited to: -Autophagy -Cancer biology -Cell adhesion and migration -Cell cycle and growth -Cell death -Chromatin and epigenetics -Cytoskeletal dynamics -Developmental biology -DNA replication and repair -Mechanisms of human disease -Mechanobiology -Membrane traffic and dynamics -Metabolism -Nuclear organization and dynamics -Organelle biology -Proteolysis and quality control -RNA biology -Signal transduction -Stem cell biology