First data on tetrodotoxins in Cephalothrix mokievskii (palaeonemertea, nemertea) and possible involvement OF POISONOUS nemerteans in toxification of marine bioresources

IF 2.6 4区医学 Q2 PHARMACOLOGY & PHARMACY

Toxicon Pub Date : 2024-10-26 DOI:10.1016/j.toxicon.2024.108155

Grigorii V. Malykin, Peter V. Velansky, Timur Yu Magarlamov

引用次数: 0

Abstract

We for the first time have recorded the presence of TTX and 11 of its analogues (TTXs) and determined the profile of these toxins by high-performance liquid chromatography–tandem mass spectrometry (HPLC-MS/MS) in Cephalothrix mokievskii, collected off the coast of Sakhalin Island and also revealed differences in the TTXs profile between C. mokievskii and sibling Cephalothrix cf, simula. We discuss the features of the TTXs profile in C. mokievskii, geographical distribution of TTX-containing nemerteans and its possible implication for toxification of marine bioresources.

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关于 Cephalothrix mokievskii（古啮齿目，啮齿目）中河豚毒素的首次数据以及有毒啮齿目动物可能参与海洋生物资源中毒的情况

我们首次通过高效液相色谱-串联质谱法（HPLC-MS/MS）记录了在萨哈林岛沿海采集的 Cephalothrix mokievskii 中存在的 TTX 及其 11 种类似物（TTXs），并确定了这些毒素的特征，同时还揭示了 Cephalothrix mokievskii 与同胞 Cephalothrix cf, simula 之间 TTXs 特征的差异。我们讨论了 C. mokievskii 的 TTXs 特征、含 TTX 的无脊椎动物的地理分布及其对海洋生物资源毒性的可能影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Toxicon 医学-毒理学

CiteScore

4.80

自引率

10.70%

发文量

358

审稿时长

68 days

期刊介绍： Toxicon has an open access mirror Toxicon: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. An introductory offer Toxicon: X - full waiver of the Open Access fee. Toxicon''s "aims and scope" are to publish: -articles containing the results of original research on problems related to toxins derived from animals, plants and microorganisms -papers on novel findings related to the chemical, pharmacological, toxicological, and immunological properties of natural toxins -molecular biological studies of toxins and other genes from poisonous and venomous organisms that advance understanding of the role or function of toxins -clinical observations on poisoning and envenoming where a new therapeutic principle has been proposed or a decidedly superior clinical result has been obtained. -material on the use of toxins as tools in studying biological processes and material on subjects related to venom and antivenom problems. -articles on the translational application of toxins, for example as drugs and insecticides -epidemiological studies on envenoming or poisoning, so long as they highlight a previously unrecognised medical problem or provide insight into the prevention or medical treatment of envenoming or poisoning. Retrospective surveys of hospital records, especially those lacking species identification, will not be considered for publication. Properly designed prospective community-based surveys are strongly encouraged. -articles describing well-known activities of venoms, such as antibacterial, anticancer, and analgesic activities of arachnid venoms, without any attempt to define the mechanism of action or purify the active component, will not be considered for publication in Toxicon. -review articles on problems related to toxinology. To encourage the exchange of ideas, sections of the journal may be devoted to Short Communications, Letters to the Editor and activities of the affiliated societies.