Natural compounds for endometriosis and related chronic pelvic pain: A review

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2024-10-28 DOI:10.1016/j.fitote.2024.106277

Agostino Zaurito , Irsida Mehmeti , Francesco Limongelli , Roberta Zupo , Alessandro Annunziato , Sergio Fontana , Roberta Tardugno

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引用次数: 0

Abstract

Endometriosis is a chronic gynecological disorder characterized by significant chronic pelvic pain (CPP) and infertility, adversely affecting the quality of life for many women worldwide.

This review aims to synthesize recent findings on natural bioactive compounds derived from various plant sources that exhibit beneficial effects in the management of endometriosis and related CPP.

A thorough search of databases, including PubMed, Scopus, and Google Scholar, was conducted to identify studies evaluating the efficacy of natural compounds on endometriosis and related CPP. In alphabetical order, curcumins, ginsenosides, polyphenols and other secondary metabolites showed promising effects on oxidative stress, inflammation, and pain modulation associated with endometriosis acting on multiple pathways. Most of the selected articles were in vitro and in vivo studies in animal models, with a limited number of clinical trials.

The reported natural compounds according to the highlighted multiple bioactivities, might be valuable complementary alternatives as supplements, nutraceuticals, or in advanced personalized nutrition. Further clinical investigations are needed to comprehensively evaluate their therapeutic potential, safety, efficacy and to establish effective treatment protocols.

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治疗子宫内膜异位症和相关慢性盆腔疼痛的天然化合物：综述

子宫内膜异位症是一种慢性妇科疾病，以严重的慢性盆腔疼痛（CPP）和不孕症为特征，对全球许多妇女的生活质量造成了不利影响。本综述旨在综合从各种植物中提取的天然生物活性化合物的最新研究成果，这些化合物在治疗子宫内膜异位症和相关的 CPP 方面表现出了有益的作用。我们对包括 PubMed、Scopus 和 Google Scholar 在内的数据库进行了全面搜索，以确定评估天然化合物对子宫内膜异位症和相关 CPP 的功效的研究。按字母顺序排列，姜黄素、人参皂苷、多酚和其他次生代谢物对与子宫内膜异位症相关的氧化应激、炎症和疼痛调节有良好的作用。所选文章大多是动物模型的体外和体内研究，临床试验数量有限。根据所强调的多种生物活性，所报道的天然化合物可能是有价值的补充剂、营养保健品或高级个性化营养品。需要进一步开展临床研究，以全面评估其治疗潜力、安全性和有效性，并制定有效的治疗方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.