Clinical parameters affect the structure and function of superficial pyramidal neurons in the adult human neocortex.

IF 4.1 Q1 CLINICAL NEUROLOGY
Brain communications Pub Date : 2024-10-07 eCollection Date: 2024-01-01 DOI:10.1093/braincomms/fcae351
Maximilian Lenz, Pia Kruse, Amelie Eichler, Jakob Straehle, Hanna Hemeling, Phyllis Stöhr, Jürgen Beck, Andreas Vlachos
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引用次数: 0

Abstract

The interplay between neuronal structure and function underpins the dynamic nature of neocortical networks. Despite extensive studies in animal models, our understanding of structure-function interrelations in the adult human brain remains incomplete. Recent methodological advances have facilitated the functional analysis of individual neurons within the human neocortex, providing a new understanding of fundamental brain processes. However, the factors contributing to patient-specific neuronal properties have not been thoroughly explored. In this observational study, we investigated the structural and functional variability of superficial pyramidal neurons in the adult human neocortex. Using whole-cell patch-clamp recordings and post hoc analyses of dendritic spine morphology in acute neocortical slice preparations from surgical resections of seven patients, we assessed age-related effects on excitatory neurotransmission, membrane properties and dendritic spine morphologies. These results specify age as an endogenous factor that might affect the structural and functional properties of superficial pyramidal neurons.

临床参数影响成人新皮层浅层锥体神经元的结构和功能。
神经元结构与功能之间的相互作用是新皮质网络动态性质的基础。尽管对动物模型进行了广泛的研究,但我们对成人大脑结构与功能之间相互关系的了解仍不全面。近年来方法学的进步促进了对人类新皮层中单个神经元的功能分析,为我们提供了对大脑基本过程的新认识。然而,导致患者特定神经元特性的因素尚未得到深入探讨。在这项观察性研究中,我们调查了成人新皮层浅层锥体神经元的结构和功能变异性。利用全细胞贴片钳记录和对七名患者手术切除的急性新皮质切片制备的树突棘形态的事后分析,我们评估了年龄对兴奋性神经递质、膜特性和树突棘形态的影响。这些结果明确指出,年龄是可能影响浅层锥体神经元结构和功能特性的内源性因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.00
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0.00%
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6 weeks
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