Maximilian Lenz, Pia Kruse, Amelie Eichler, Jakob Straehle, Hanna Hemeling, Phyllis Stöhr, Jürgen Beck, Andreas Vlachos
{"title":"Clinical parameters affect the structure and function of superficial pyramidal neurons in the adult human neocortex.","authors":"Maximilian Lenz, Pia Kruse, Amelie Eichler, Jakob Straehle, Hanna Hemeling, Phyllis Stöhr, Jürgen Beck, Andreas Vlachos","doi":"10.1093/braincomms/fcae351","DOIUrl":null,"url":null,"abstract":"<p><p>The interplay between neuronal structure and function underpins the dynamic nature of neocortical networks. Despite extensive studies in animal models, our understanding of structure-function interrelations in the adult human brain remains incomplete. Recent methodological advances have facilitated the functional analysis of individual neurons within the human neocortex, providing a new understanding of fundamental brain processes. However, the factors contributing to patient-specific neuronal properties have not been thoroughly explored. In this observational study, we investigated the structural and functional variability of superficial pyramidal neurons in the adult human neocortex. Using whole-cell patch-clamp recordings and <i>post hoc</i> analyses of dendritic spine morphology in acute neocortical slice preparations from surgical resections of seven patients, we assessed age-related effects on excitatory neurotransmission, membrane properties and dendritic spine morphologies. These results specify age as an endogenous factor that might affect the structural and functional properties of superficial pyramidal neurons.</p>","PeriodicalId":93915,"journal":{"name":"Brain communications","volume":null,"pages":null},"PeriodicalIF":4.1000,"publicationDate":"2024-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11518857/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/braincomms/fcae351","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q1","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The interplay between neuronal structure and function underpins the dynamic nature of neocortical networks. Despite extensive studies in animal models, our understanding of structure-function interrelations in the adult human brain remains incomplete. Recent methodological advances have facilitated the functional analysis of individual neurons within the human neocortex, providing a new understanding of fundamental brain processes. However, the factors contributing to patient-specific neuronal properties have not been thoroughly explored. In this observational study, we investigated the structural and functional variability of superficial pyramidal neurons in the adult human neocortex. Using whole-cell patch-clamp recordings and post hoc analyses of dendritic spine morphology in acute neocortical slice preparations from surgical resections of seven patients, we assessed age-related effects on excitatory neurotransmission, membrane properties and dendritic spine morphologies. These results specify age as an endogenous factor that might affect the structural and functional properties of superficial pyramidal neurons.