Spectrofluorometric Turn-Off Sensing Probe for Tolmetin Determination Using Cerium and Nitrogen Codoped Carbon Dots

IF 3.2 4区化学 Q2 CHEMISTRY, ANALYTICAL

Luminescence Pub Date : 2024-10-29 DOI:10.1002/bio.70008

Mokhtar M. Mabrouk, Fotouh R. Mansour, Hamsa B. Hassan, Aya A. Abdella

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Abstract

A facile, low-cost, and rapid method was developed for spectrofluorometric determination of tolmetin (TOL) using highly fluorescent (QY = 35%) cerium and nitrogen codoped carbon dots (Ce–NCDs) sensing platform prepared by one-step hydrothermal method. Owing to the severe overlap between TOL absorption and Ce–NCDs excitation spectra around 320 nm, TOL could attenuate the emission of Ce–NCDs at 407 nm through primary inner filter effect (IFE). This concentration dependent attenuation was linear between 2 and 10 μg/mL (r = 0.9993) with a limit of detection of 0.5 μg/mL. The sensor showed very good accuracy (% recovery = 98%–100%) and precision (%RSD < 2). The developed sensing strategy was successfully applied for TOL detection as an active pharmaceutical ingredient in pharmaceutical formulation and as a potential pollutant in environmental water samples, such as tap and river water, with acceptable recovery and considerable selectivity. Thus, the direct single-step spectrofluorometric determination of TOL was enabled without extensive processing or chemical derivatization.

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使用铈和氮掺杂碳点测定托美汀的分光荧光熄灭传感探针

利用一步水热法制备的高荧光（QY = 35%）铈氮共掺杂碳点（Ce-NCDs）传感平台，建立了一种简便、低成本、快速的分光荧光测定托美丁（TOL）的方法。由于 TOL 的吸收光谱与 Ce-NCDs 在 320 纳米附近的激发光谱严重重叠，TOL 可以通过初级内滤光片效应（IFE）衰减 Ce-NCDs 在 407 纳米的发射光谱。这种与浓度相关的衰减在 2 至 10 μg/mL 之间呈线性关系（r = 0.9993），检测限为 0.5 μg/mL。该传感器显示出非常好的准确度（回收率 = 98%-100%）和精密度（%RSD

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来源期刊

Luminescence 生物-生化与分子生物学

CiteScore

5.10

自引率

13.80%

发文量

248

审稿时长

3.5 months

期刊介绍： Luminescence provides a forum for the publication of original scientific papers, short communications, technical notes and reviews on fundamental and applied aspects of all forms of luminescence, including bioluminescence, chemiluminescence, electrochemiluminescence, sonoluminescence, triboluminescence, fluorescence, time-resolved fluorescence and phosphorescence. Luminescence publishes papers on assays and analytical methods, instrumentation, mechanistic and synthetic studies, basic biology and chemistry. Luminescence also publishes details of forthcoming meetings, information on new products, and book reviews. A special feature of the Journal is surveys of the recent literature on selected topics in luminescence.