Evaluation of mandibular bone structure changes in phenylketonuria patients through fractal analysis and radiomorphometric indices.

IF 2 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2024-10-05 DOI:10.1016/j.oooo.2024.09.011

Hazal Duyan Yüksel, Damla Soydan Çabuk, Ali İhsan Çabuk, Burcu Evlice

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引用次数: 0

Abstract

Objectives: The aim of this study was to evaluate the effect of phenylketonuria (PKU) on mandibular bone structure by comparing the bone of PKU patients with healthy controls using fractal analysis (FA) and the radiomorphometric indices of mandibular cortical width (MCW) and mandibular cortical index (MCI).

Study design: In total, 32 patients with PKU were analyzed and compared with the control participants. Regions of interest in panoramic radiographs were selected and the fractal dimension (FD) obtained from FA was calculated. MCW was defined as the cortical thickness of the inferior border of the mandible at the level of the mental foramen. MCI classified the endosteal edge of the mandibular cortex as C1: straight and sharp, C2: the presence lacunar resorption spaces, and C3: distinctly porous and severely eroded. The significance level was P < .05.

Results: All FD and MCW values were significantly lower in the PKU patients. The prevalence of C1 was significantly lower and prevalence of C2 was significantly higher in the PKU group.

Conclusions: The differences in FD and radiomorphometric indices between patients with PKU and healthy controls may indicate a potential impact of PKU on mandibular bone structure.

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通过分形分析和放射形态测量指数评估苯丙酮尿症患者下颌骨结构的变化。

研究目的本研究旨在通过分形分析（FA）以及下颌骨皮质宽度（MCW）和下颌骨皮质指数（MCI）等放射形态计量指标，比较PKU患者和健康对照组的骨骼，从而评估苯丙酮尿症（PKU）对下颌骨结构的影响：研究设计：共对32名PKU患者进行了分析，并与对照组参与者进行了比较。选取全景X光片上的感兴趣区，计算从FA获得的分形维度（FD）。MCW被定义为下颌骨下缘在精神孔水平的皮质厚度。MCI 将下颌骨皮质的骨内缘分为 C1：直而锋利；C2：存在裂隙吸收空间；C3：明显多孔和严重侵蚀。显著性水平为 P <0.05：PKU患者的所有FD值和MCW值都明显较低。PKU组C1的患病率明显较低，C2的患病率明显较高：结论：PKU患者与健康对照组在FD和放射形态计量指数上的差异可能表明PKU对下颌骨结构有潜在影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral Surgery Oral Medicine Oral Pathology Oral Radiology DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.80

自引率

6.90%

发文量

1217

审稿时长

2-4 weeks

期刊介绍： Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology is required reading for anyone in the fields of oral surgery, oral medicine, oral pathology, oral radiology or advanced general practice dentistry. It is the only major dental journal that provides a practical and complete overview of the medical and surgical techniques of dental practice in four areas. Topics covered include such current issues as dental implants, treatment of HIV-infected patients, and evaluation and treatment of TMJ disorders. The official publication for nine societies, the Journal is recommended for initial purchase in the Brandon Hill study, Selected List of Books and Journals for the Small Medical Library.