Outcomes of the effect of exercise on cognitive function in patients with depression: A meta-analysis.

IF 3.9 4区医学 Q1 PSYCHIATRY

World Journal of Psychiatry Pub Date : 2024-10-19 DOI:10.5498/wjp.v14.i10.1558

Xiao-Zhen Guo, Cong Liu, Jing Wang, Hai-Rong Liu

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引用次数: 0

Abstract

Background: Major depressive disorder is a common mental disorder, characterized by a high rate of suicide and recurrence, which is frequently accompanied by cognitive impairments, particularly in executive function, memory, attention, and information processing speed. As such, improving the cognitive function in patients with depression and enhancing their quality of life are urgent issues.

Aim: To perform a systematic review and meta-analysis of the effects of exercise on cognitive function in patients with depression.

Methods: The PubMed, Web of Science, Cochrane Library, Embase, China National Knowledge Infrastructure, Wanfang Medical, VIP, and Biomedical Databases for randomized controlled trials (RCTs) databases were searched (from inception to October 19, 2023) for studies investigating improvements in cognitive function in patients with depression through exercise. Tools recommended by the Cochrane Handbook for RCT evaluation, and GRADEpro and Stata17 software, were employed for risk of bias assessment, evidence grading, forest plot construction, subgroup and sensitivity analyses, and assessment of publication bias.

Results: Seventeen RCTs (1173 patients with depression) were included. Exercise had a small but significant positive effect on attention, with an effect size of 0.21, 95%CI: 0.07-0.34, P < 0.01. Specifically, aerobic exercise regimens of 30-60 minute/session, thrice a week, at moderate intensity, and sustained over 3-12 weeks, were associated with the most pronounced benefits (P < 0.05), with effect sizes for executive function, memory, and information processing speed of 0.11, 95%CI: -0.11-0.32, P = 0.34; 0.08, 95%CI: 0.00-0.16, P = 0.05; and 0.14, 95%CI: 0.04-0.25, P = 0.01, respectively. The evidence levels for attention, information processing speed, and memory were rated as 'low,' whereas that for executive function was rated as 'very low'.

Conclusion: Exercise could improve attention and information-processing speed in patients with depression, although improvements in executive function and memory are not significant.

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运动对抑郁症患者认知功能的影响结果：荟萃分析

背景介绍重度抑郁症是一种常见的精神障碍，其特点是自杀率和复发率高，并经常伴有认知功能障碍，尤其是在执行功能、记忆力、注意力和信息处理速度方面。因此，改善抑郁症患者的认知功能、提高其生活质量是亟待解决的问题。目的：对运动对抑郁症患者认知功能的影响进行系统回顾和荟萃分析：方法：在PubMed、Web of Science、Cochrane Library、Embase、中国国家知识基础设施、万方医学、VIP和生物医学数据库的随机对照试验（RCTs）数据库中检索（从开始到2023年10月19日）通过运动改善抑郁症患者认知功能的研究。采用《Cochrane 手册》推荐的 RCT 评估工具以及 GRADEpro 和 Stata17 软件进行偏倚风险评估、证据分级、森林图构建、亚组和敏感性分析以及发表偏倚评估：结果：共纳入 17 项研究性临床试验（1173 名抑郁症患者）。运动对注意力有微小但显著的积极影响，效应大小为0.21，95%CI：0.07-0.34，P < 0.01。具体来说，每周三次、每次30-60分钟、中等强度、持续3-12周的有氧运动方案能带来最明显的益处（P < 0.05），对执行功能、记忆力和信息处理速度的效应大小分别为0.11（95%CI：-0.11-0.32，P = 0.34）、0.08（95%CI：0.00-0.16，P = 0.05）和0.14（95%CI：0.04-0.25，P = 0.01）。注意力、信息处理速度和记忆力的证据等级被评为 "低"，而执行功能的证据等级被评为 "极低"：结论：运动可以改善抑郁症患者的注意力和信息处理速度，但对执行功能和记忆力的改善并不显著。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World Journal of Psychiatry PSYCHIATRY-

自引率

6.50%

发文量

110

期刊介绍： The World Journal of Psychiatry (WJP) is a high-quality, peer reviewed, open-access journal. The primary task of WJP is to rapidly publish high-quality original articles, reviews, editorials, and case reports in the field of psychiatry. In order to promote productive academic communication, the peer review process for the WJP is transparent; to this end, all published manuscripts are accompanied by the anonymized reviewers’ comments as well as the authors’ responses. The primary aims of the WJP are to improve diagnostic, therapeutic and preventive modalities and the skills of clinicians and to guide clinical practice in psychiatry.