Internalizing disorders rather than ADHD are risk factors for chronicity in pediatric migraine patients.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-07-12 eCollection Date: 2024-01-01 DOI:10.55730/1300-0144.5870

Nevra Öksüz, Gülen Güler Aksu, Asena Ayça Özdemir, Aynur Özge

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引用次数: 0

Abstract

Background/aim: Migraine is a prevalent neurological disorder that can lead to disability in children and adolescents. It is frequently accompanied by psychiatric comorbidities, both internalizing and externalizing disorders. While the relationship between migraine and internalizing disorders has been studied, there is limited research on the link between migraine and attention deficit hyperactivity disorder (ADHD).

Materials and methods: A total of 280 pediatric headache patients, 107 with externalizing (ADHD) and 173 with internalizing disorders (depression and/or anxiety), were included. The dataset was composed using the Turkish headache database, Mersin Branch. Pain characteristics, associated symptoms, and accompanying comorbidities were evaluated retrospectively.

Results: Two hundred four patients were followed up with episodic migraine (EM) and 76 patients with chronic migraine (CM). One hundred forty-six boys and 134 girls were evaluated, and internalizing disorders were more common in the girls (p < 0.001). It was a much more prominent accompaniment in chronic migraine internalizing disorders (p = 0.038). EM, on the other hand, was more frequent in ADHD. Pain intensity and frequency were greater in those with internalizing disorders (p = 0.007), while photophobia was more prevalent in those with ADHD (OR; 0.555, p = 0.044). Moreover, we observed that individuals with internalizing disorders were predominantly female (p = 0.003) and had a higher mean age (p < 0.001) than those with externalizing disorders.

Conclusion: Internalizing disorders seem to be a risk factor for migraine chronification in pediatric migraine. ADHD is a prototypic externalizing disorder more associated with EM. This outcome provides an opportunity to follow our patients in terms of prognosis and offers us the chance for a better evaluation. Identifying factors that contribute to the chronicity of migraine may lead to better management and reduced disability for migraine sufferers.

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内化障碍而非多动症是导致儿童偏头痛患者慢性化的危险因素。

背景/目的：偏头痛是一种常见的神经系统疾病，可导致儿童和青少年残疾。它经常伴有精神并发症，包括内化障碍和外化障碍。虽然偏头痛与内化性障碍之间的关系已得到研究，但有关偏头痛与注意缺陷多动障碍（ADHD）之间关系的研究却很有限：共纳入280名小儿头痛患者，其中107人患有外化障碍（多动症），173人患有内化障碍（抑郁症和/或焦虑症）。数据集由土耳其头痛数据库梅尔辛分部提供。对疼痛特征、相关症状和伴随的合并症进行了回顾性评估：结果：对 244 名发作性偏头痛（EM）患者和 76 名慢性偏头痛（CM）患者进行了随访。对146名男孩和134名女孩进行了评估，发现内化障碍在女孩中更为常见（P < 0.001）。在慢性偏头痛患者中，内化性障碍更为常见（p = 0.038）。另一方面，EM在多动症中更为常见。内化障碍患者的疼痛强度和频率更高（p = 0.007），而多动症患者的畏光现象更为普遍（OR；0.555，p = 0.044）。此外，我们还观察到，内化障碍患者主要为女性（p = 0.003），平均年龄（p < 0.001）高于外化障碍患者：结论：内化性障碍似乎是儿童偏头痛慢性化的一个危险因素。结论：内化性障碍似乎是儿童偏头痛慢性化的危险因素，而多动症是一种典型的外化性障碍，与偏头痛的关系更为密切。这一结果为我们跟踪患者的预后提供了机会，也为我们提供了更好的评估机会。找出导致偏头痛慢性化的因素可能会使偏头痛患者得到更好的管理并减少残疾。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.