Quality of life of inflammatory bowel diseases patients in france with EQ-5D-5 L: the QALY-MICI study.

IF 3.3 3区医学 Q1 HEALTH CARE SCIENCES & SERVICES

Quality of Life Research Pub Date : 2024-10-29 DOI:10.1007/s11136-024-03821-x

H Sarter, J Kirschgesner, L Beaugerie, A Buisson, C Gower-Rousseau, Gérard de Pouvourville

{"title":"Quality of life of inflammatory bowel diseases patients in france with EQ-5D-5 L: the QALY-MICI study.","authors":"H Sarter, J Kirschgesner, L Beaugerie, A Buisson, C Gower-Rousseau, Gérard de Pouvourville","doi":"10.1007/s11136-024-03821-x","DOIUrl":null,"url":null,"abstract":"Purpose: This study aimed to document utility values and the Visual Analog Scale (VAS) with the 5-level version of the EQ-5D questionnaire in a large sample of patients with inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC).Methods: QALY-MICI was a cross-sectional survey across three sources in France. Data were collected between 2019 and 2022 for patients 18 and over. The EQ-5D-5 L, the EQ-VAS, the Short Inflammatory Bowel Disease Questionnaire (SIBDQ), the Harvey-Bradshaw Index (HBI) for CD, and the Walmsley Index for UC (SCCAI) were collected.Results: A total of 2,841 patients aged over 18 were recruited (1785 with CD, 1056 with UC). The mean age was 40.2 (SD 14.3). The time since diagnosis was 6 years and over for 61.9% of patients. The most impacted dimensions were usual activities, anxiety/ depression, and pain/ discomfort. The mean utility value was 0.863 (SD 0.172) versus 0.905 (SD 0.158) in the French population (p = 0.007). The mean VAS value was 68 (SD 19.2) versus 73.4 (SD 22.2) in the general population (p = 0.016). Utility values and VAS were similar for CD and UC and higher for men. There was a strong positive correlation between utility values, the VAS, and the SIBDQ score, and a negative correlation between the HBI and the SCCAI. The SIBDQ score and disease activity were the main predictors of utility and VAS.Conclusion: The QALY-MICI is, to our knowledge, the first study documenting utility values and VAS using the EQ-5D-5 L questionnaire on a large sample, with a comparison to the general population.","PeriodicalId":20748,"journal":{"name":"Quality of Life Research","volume":null,"pages":null},"PeriodicalIF":3.3000,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Quality of Life Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s11136-024-03821-x","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"HEALTH CARE SCIENCES & SERVICES","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: This study aimed to document utility values and the Visual Analog Scale (VAS) with the 5-level version of the EQ-5D questionnaire in a large sample of patients with inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC).

Methods: QALY-MICI was a cross-sectional survey across three sources in France. Data were collected between 2019 and 2022 for patients 18 and over. The EQ-5D-5 L, the EQ-VAS, the Short Inflammatory Bowel Disease Questionnaire (SIBDQ), the Harvey-Bradshaw Index (HBI) for CD, and the Walmsley Index for UC (SCCAI) were collected.

Results: A total of 2,841 patients aged over 18 were recruited (1785 with CD, 1056 with UC). The mean age was 40.2 (SD 14.3). The time since diagnosis was 6 years and over for 61.9% of patients. The most impacted dimensions were usual activities, anxiety/ depression, and pain/ discomfort. The mean utility value was 0.863 (SD 0.172) versus 0.905 (SD 0.158) in the French population (p = 0.007). The mean VAS value was 68 (SD 19.2) versus 73.4 (SD 22.2) in the general population (p = 0.016). Utility values and VAS were similar for CD and UC and higher for men. There was a strong positive correlation between utility values, the VAS, and the SIBDQ score, and a negative correlation between the HBI and the SCCAI. The SIBDQ score and disease activity were the main predictors of utility and VAS.

Conclusion: The QALY-MICI is, to our knowledge, the first study documenting utility values and VAS using the EQ-5D-5 L questionnaire on a large sample, with a comparison to the general population.

查看原文本刊更多论文

法国炎症性肠病患者的 EQ-5D-5 L 生活质量：QALY-MICI 研究。

目的：本研究旨在记录包括克罗恩病（CD）和溃疡性结肠炎（UC）在内的炎症性肠病（IBD）大样本患者的效用值和五级版 EQ-5D 问卷的视觉模拟量表（VAS）：QALY-MICI 是一项横断面调查，涉及法国的三个来源。数据收集时间为 2019 年至 2022 年，对象为 18 岁及以上的患者。调查收集了 EQ-5D-5 L、EQ-VAS、炎症性肠病简短问卷（SIBDQ）、CD 的哈维-布拉德肖指数（HBI）和 UC 的沃姆斯利指数（SCCAI）：共招募了 2841 名 18 岁以上的患者（其中 CD 患者 1785 名，UC 患者 1056 名）。平均年龄为 40.2 岁（SD 14.3）。61.9%的患者确诊时间超过 6 年。影响最大的方面是日常活动、焦虑/抑郁和疼痛/不适。平均效用值为 0.863（标清 0.172），而法国人群的效用值为 0.905（标清 0.158）（P = 0.007）。VAS 平均值为 68（标准差 19.2），而普通人群为 73.4（标准差 22.2）（p = 0.016）。CD 和 UC 的效用值和 VAS 值相似，男性的效用值更高。效用值、VAS 和 SIBDQ 评分之间存在很强的正相关性，而 HBI 和 SCCAI 之间存在负相关。SIBDQ评分和疾病活动是预测效用值和VAS的主要因素：据我们所知，QALY-MICI 是第一项使用 EQ-5D-5 L 问卷对大样本进行效用值和 VAS 记录的研究，并与普通人群进行了比较。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Quality of Life Research 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.50

自引率

8.60%

发文量

224

审稿时长

3-8 weeks

期刊介绍： Quality of Life Research is an international, multidisciplinary journal devoted to the rapid communication of original research, theoretical articles and methodological reports related to the field of quality of life, in all the health sciences. The journal also offers editorials, literature, book and software reviews, correspondence and abstracts of conferences. Quality of life has become a prominent issue in biometry, philosophy, social science, clinical medicine, health services and outcomes research. The journal''s scope reflects the wide application of quality of life assessment and research in the biological and social sciences. All original work is subject to peer review for originality, scientific quality and relevance to a broad readership. This is an official journal of the International Society of Quality of Life Research.