The Oxente Chagas Bahia Project: evaluating the efficacy of a rapid diagnostic test and treatments for Chagas disease.

IF 2.5 4区医学 Q2 PARASITOLOGY

Memorias do Instituto Oswaldo Cruz Pub Date : 2024-10-28 eCollection Date: 2024-01-01 DOI:10.1590/0074-02760240140

Fred Luciano Neves Santos, Tycha Bianca Sabaini Pavan, Cristiane Siqueira Valle, Daniel Dias Sampaio, Larissa Carvalho Medrado Vasconcelos, Maria Hermoso Cristóbal, Ângelo Antônio Oliveira Silva, Cátia Martins de Oliveira, Raquel Santos de Souza, Carmen Nila Phang Romero Casas, André Daher, Isadora Cristina de Siqueira

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Abstract

Chagas disease (CD), caused by Trypanosoma cruzi, is a life-threatening neglected anthropozoonosis primarily transmitted by triatomine bugs. Affecting an estimated 5.7 million people globally, CD has significant morbidity and mortality, particularly in Latin America. The Oxente Chagas Bahia Project aims to screen approximately 30,000 individuals, validate a rapid diagnostic test in a real-world setting, and provide crucial data on its diagnostic performance and cost-effectiveness. Additionally, a biobank will be established to support further research on disease biomarkers and treatment cure rates. By enhancing access to timely diagnosis and treatment, the project will evaluate a strategy to reduce the CD burden.

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Oxente 巴伊亚恰加斯病项目：评估恰加斯病快速诊断检测和治疗方法的效果。

恰加斯病（CD）由克鲁斯锥虫引起，是一种被忽视的炭疽病，主要通过三蠹蝽传播，危及生命。据估计，全球有 570 万人患有南美锥虫病，发病率和死亡率都很高，尤其是在拉丁美洲。Oxente 巴伊亚恰加斯病项目旨在筛查约 30,000 人，在实际环境中验证快速诊断测试，并提供有关其诊断性能和成本效益的重要数据。此外，还将建立一个生物库，以支持对疾病生物标志物和治疗治愈率的进一步研究。通过提高及时诊断和治疗的可及性，该项目将对减轻 CD 负担的战略进行评估。

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来源期刊

Memorias do Instituto Oswaldo Cruz 医学-寄生虫学

CiteScore

5.00

自引率

3.60%

发文量

审稿时长

3-8 weeks

期刊介绍： Memórias do Instituto Oswaldo Cruz is a journal specialized in microbes & their vectors causing human infections. This means that we accept manuscripts covering multidisciplinary approaches and findings in the basic aspects of infectious diseases, e.g. basic in research in prokariotes, eukaryotes, and/or virus. Articles must clearly show what is the main question to be answered, the hypothesis raised, and the contribution given by the study. Priority is given to manuscripts reporting novel mechanisms and general findings concerning the biology of human infectious prokariotes, eukariotes or virus. Papers reporting innovative methods for diagnostics or that advance the basic research with these infectious agents are also welcome. It is important to mention what we do not publish: veterinary infectious agents research, taxonomic analysis and re-description of species, epidemiological studies or surveys or case reports and data re-analysis. Manuscripts that fall in these cases or that are considered of low priority by the journal editorial board, will be returned to the author(s) for submission to another journal.