Histopathological Findings of Epithelial Invasion after Arcuate and Radial Keratotomies.

IF 0.8 4区 医学 Q4 OPHTHALMOLOGY
Alexandra Serfözö, Fidelis Flockerzi, Tim Berger, Adrien Quintin, Berthold Seitz
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引用次数: 0

Abstract

Background: Complications after arcuate (АKs) and radial keratotomies (RKs) may include infection, delayed wound healing, and epithelial invasion.

Purpose: To assess the histopathologic findings of epithelial invasion following АK/RK.

Methods: The study included patients who underwent penetrating keratoplasty (PK) after previous АK or RK treatment. In corneas with histologically confirmed epithelial invasion, the following parameters were examined: invasion depth (µm), width (µm) in the superficial, middle, and deep stroma, and the ratio of invasion depth to corneal thickness. The time between АK/RK and PK was compared for corneas with and without detectable epithelial invasion.

Results: Out of 31 excised corneas, 7 (22%) showed epithelial invasion 2 to 19 years (median 6 years) after АK/RK. Histological examination revealed different invasion patterns, with a mean depth of 315 (231 to 395) µm or 57% (46 to 66%) of corneal thickness. The mean width in the superficial stroma was 291 (75 to 789) µm, in the middle stroma 210 (33 to 422) µm, and in the deep stroma 164 (19 to 324) µm. No significant association was found between the presence of the epithelial invasion and the time after PK (p = 0.83).

Conclusion: In almost a quarter of the eyes after АK or RK, epithelial invasion could be detected. The potential biomechanical instability associated with this should be considered in cases of trauma as well as in the context of planning cataract surgery or PK, particularly in the hands of less experienced surgeons. Nonmechanical contact-free excimer laser trephination may be helpful in PK.

弧形和放射状角膜切开术后上皮侵袭的组织病理学发现。
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来源期刊
CiteScore
1.30
自引率
0.00%
发文量
235
审稿时长
4-8 weeks
期刊介绍: -Konzentriertes Fachwissen aus Klinik und Praxis: Die entscheidenden Ergebnisse der internationalen Forschung - für Sie auf den Punkt gebracht und kritisch kommentiert, Übersichtsarbeiten zu den maßgeblichen Themen der täglichen Praxis, Top informiert - breite klinische Berichterstattung. -CME-Punkte sammeln mit dem Refresher: Effiziente, CME-zertifizierte Fortbildung, mit dem Refresher, 3 CME-Punkte pro Ausgabe - bis zu 36 CME-Punkte im Jahr!. -Aktuelle Rubriken mit echtem Nutzwert: Kurzreferate zu den wichtigsten Artikeln internationaler Zeitschriften, Schwerpunktthema in jedem Heft: Ausführliche Übersichtsarbeiten zu den wichtigsten Themen der Ophthalmologie – so behalten Sie das gesamte Fach im Blick!, Originalien mit den neuesten Entwicklungen, Übersichten zu den relevanten Themen.
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