Histopathological spectrum of primordial odontogenic tumor with co-existing dentigerous cyst: 1^st reported case of the world with a proposed 'updated diagnostic criteria'.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-10-29 DOI:10.1186/s13000-024-01560-8

Dhara Dwivedi, Nitin Prabhakar, Monal Yuwanati, Gunjan S Aswal, Renu Rawat

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引用次数: 0

Abstract

Background: POT is a relatively newly described benign odontogenic tumor with very few cases registered to date. We present the 1st case of Primordial odontogenic tumor (POT) from Sub-Saharan Africa with unique clinicopathological features; also, this is the first case to report POT's existence as a Hybrid Odontogenic lesion (HOL), with a pertinent review of the literature.

Case presentation: This was a 17-year-old patient who presented with slow-growing, painless posterior mandibular swelling. The imaging revealed a well-defined, unilocular, expansile, lytic lesion with internal calcific foci surrounding an impacted #36, indicating a calcifying odontogenic cyst. The incisional biopsy revealed the presence of POT. The tumor was excised along with the involved tooth.

Conclusion: POT is predominantly a non-aggressive and mostly affects the pediatric population. Hence, clinicians must be updated on all the aspects of this tumor to diagnose it appropriately and avoid any undue over-or under-treatment.

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原始牙源性肿瘤与牙源性囊肿并存的组织病理学特征：全球首例报告病例，并提出 "最新诊断标准"。

背景：原始牙源性肿瘤（POT）是一种较新描述的良性牙源性肿瘤，迄今为止登记在册的病例极少。我们报告了第一例来自撒哈拉以南非洲的原始牙源性肿瘤（POT），该病例具有独特的临床病理特征；这也是第一例报告原始牙源性肿瘤作为混合性牙源性病变（HOL）存在的病例，并对文献进行了相关回顾：这是一名 17 岁的患者，因下颌骨后部肿物生长缓慢、无痛而就诊。影像学检查显示，患者的下颌后部肿物轮廓清晰、单球形、膨胀性、溶解性病变，内部有钙化灶，周围有一颗撞击性的 36 号牙，这表明患者患上了钙化性牙源性囊肿。切口活检显示存在 POT。肿瘤连同受累牙齿一起切除：结论：POT 主要是一种非侵袭性肿瘤，多发于儿童群体。因此，临床医生必须了解该肿瘤的所有方面，以便做出正确诊断，避免过度治疗或治疗不当。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464