Predictive value of metabolic parameters and apparent diffusion coefficient derived from 18F-FDG PET/MR in patients with non-small cell lung cancer.

IF 2.9 3区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

BMC Medical Imaging Pub Date : 2024-10-29 DOI:10.1186/s12880-024-01445-8

Han Jiang, Ziqiang Li, Nan Meng, Yu Luo, Pengyang Feng, Fangfang Fu, Yang Yang, Jianmin Yuan, Zhe Wang, Meiyun Wang

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引用次数: 0

Abstract

Background: Multiple models intravoxel incoherent motion (IVIM) based ¹⁸F-fluorodeoxyglucose positron emission tomography-magnetic resonance(¹⁸F-FDG PET/MR) could reflect the microscopic information of the tumor from multiple perspectives. However, its value in the prognostic assessment of non-small cell lung cancer (NSCLC) still needs to be further explored.

Objective: To compare the value of ¹⁸F-FDG PET/MR metabolic parameters and diffusion parameters in the prognostic assessment of patients with NSCLC.

Meterial and methods: Chest PET and IVIM scans were performed on 61 NSCLC patients using PET/MR. The maximum standard uptake value (SUV_max), metabolic tumor volume (MTV), total lesion glycolysis (TLG), diffusion coefficient (D), perfusion fraction (f), pseudo diffusion coefficient (D*) and apparent diffusion coefficient (ADC) were calculated. The impact of SUV_max, MTV, TLG, D, f, D*and ADC on survival was measured in terms of the hazard ratio (HR) effect size. Overall survival time (OS) and progression-free survival time (PFS) were evaluated with the Kaplan-Meier and Cox proportional hazard models. Log-rank test was used to analyze the differences in parameters between groups.

Results: 61 NSCLC patients had an overall median OS of 18 months (14.75, 22.85) and a median PFS of 17 months (12.00, 21.75). Univariate analysis showed that pathological subtype, TNM stage, surgery, SUV_max, MTV, TLG, D, D* and ADC were both influential factors for OS and PFS in NSCLC patients. Multifactorial analysis showed that MTV, D* and ADC were independent predicting factors for OS and PFS in NSCLC patients.

Conclusion: MTV, D* and ADC are independent predicting factors affecting OS and PFS in NSCLC patients. ¹⁸F-FDG PET/MR-derived metabolic parameters and diffusion parameters have clinical value for prognostic assessment of NSCLC patients.

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从 18F-FDG PET/MR 中得出的非小细胞肺癌患者代谢参数和表观扩散系数的预测价值。

背景：基于18F-氟脱氧葡萄糖正电子发射断层扫描-磁共振（18F-FDG PET/MR）的多模型体素内非相干运动（IVIM）可从多个角度反映肿瘤的微观信息。然而，它在非小细胞肺癌（NSCLC）预后评估中的价值仍有待进一步探讨：比较 18F-FDG PET/MR 代谢参数和弥散参数在非小细胞肺癌患者预后评估中的价值：使用 PET/MR 对 61 名 NSCLC 患者进行胸部 PET 和 IVIM 扫描。计算了最大标准摄取值（SUVmax）、代谢肿瘤体积（MTV）、总病变糖酵解（TLG）、扩散系数（D）、灌注分数（f）、假扩散系数（D*）和表观扩散系数（ADC）。SUVmax、MTV、TLG、D、f、D*和ADC对生存期的影响以危险比（HR）效应大小来衡量。总生存时间（OS）和无进展生存时间（PFS）采用 Kaplan-Meier 模型和 Cox 比例危险模型进行评估。对数秩检验用于分析组间参数的差异：61名NSCLC患者的总中位OS为18个月（14.75，22.85），中位PFS为17个月（12.00，21.75）。单变量分析显示，病理亚型、TNM 分期、手术、SUVmax、MTV、TLG、D、D* 和 ADC 都是影响 NSCLC 患者 OS 和 PFS 的因素。多因素分析显示，MTV、D*和ADC是NSCLC患者OS和PFS的独立预测因素：结论：MTV、D*和ADC是影响NSCLC患者OS和PFS的独立预测因素。18F-FDG PET/MR衍生代谢参数和弥散参数对NSCLC患者的预后评估具有临床价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Medical Imaging RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

4.60

自引率

3.70%

发文量

198

审稿时长

27 weeks

期刊介绍： BMC Medical Imaging is an open access journal publishing original peer-reviewed research articles in the development, evaluation, and use of imaging techniques and image processing tools to diagnose and manage disease.