Association of Transient Global Amnesia (TGA) With Dietary Intake of Vitamin B12.

IF 2.1 4区心理学 Q2 PSYCHOLOGY

Archives of Clinical Neuropsychology Pub Date : 2024-10-29 DOI:10.1093/arclin/acae091

Seyedeh Hayedeh Mousavi Shalmani, Zahra Mahamoudi, Narjes Nooriani, Zahra Saeedirad, Naeemeh Hassanpour Ardekanizadeh, Aryan Tavakoli, Soheila Shekari, Masoomeh Alsadat Mirshafaei, Mahdi Mousavi Mele, Pouya Mirzaee, Maryam Gholamalizadeh, Parsa Bahmani, Sara Khoshdooz, Saeid Doaei

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引用次数: 0

Abstract

Background: Transient global amnesia (TGA), which is described as short-term amnesia, may be influenced by some dietary components involved in brain function. The aim of the present study was to assess the connection between TGA and dietary intake of vitamin B12.

Methods: This cross-sectional study was conducted on 258 people with TGA and 520 people without TGA in Sabzevar, Iran. All participants were screened for TGA (ICD-10 code: G45.4). A validated Food Frequency Questionnaire (FFQ) was utilized to estimate the dietary intake of vitamin B12. Different models of logistic regression were used to determine the association between TGA and dietary intake of vitamin B12 after adjusting the confounders.

Results: There was an inverse association between the risk of TGA and the intake of vitamin B12 (OR = 0.94, CI 95%: 0.89-0.99, p = .02, effect size: -0.04). The result did not change after adjustment for age, gender, education, job, and marital status (OR = 0.93, CI 95%: 0.88-0.98, p = .01, effect size: -0.03). The result remained significant after additional adjustments for body mass index (BMI) and physical activity (OR = 0.94, CI 95%: 0.89-0.99, p = .03, effect size: -0.04), and after further adjustments for the underlying diseases, including diabetes, hypertension, and stroke (OR = 0.86, CI 95%: 0.81-0.92, p < .01, effect size: -0.10).

Conclusion: Vitamin B12 deficiency may increase the risk of TGA and should be considered as a potential concern for people at risk for TGA. Further studies are needed to validate these findings and to discover the underlying mechanisms of the effects of vitamin B12 on TGA.

查看原文本刊更多论文

短暂性全面健忘症 (TGA) 与膳食中维生素 B12 摄入量的关系。

背景：短暂性全局健忘症（TGA）被描述为短期健忘症，可能会受到一些与大脑功能有关的膳食成分的影响。本研究旨在评估 TGA 与维生素 B12 膳食摄入量之间的关系：这项横断面研究在伊朗萨布泽瓦尔对 258 名 TGA 患者和 520 名非 TGA 患者进行了调查。所有参与者均接受了 TGA 筛查（ICD-10 代码：G45.4）。采用经过验证的食物频率问卷（FFQ）来估算维生素 B12 的膳食摄入量。在调整混杂因素后，采用不同的逻辑回归模型来确定 TGA 与维生素 B12 膳食摄入量之间的关系：结果：TGA的风险与维生素B12的摄入量呈负相关（OR = 0.94，CI 95%：0.89-0.99，P = .02，效应大小：-0.04）。在对年龄、性别、教育程度、工作和婚姻状况进行调整后，结果没有变化（OR = 0.93，CI 95%：0.88-0.98，P = 0.01，效应大小：-0.03）。在对体重指数（BMI）和体力活动（OR = 0.94，CI 95%：0.89-0.99，p = .03，效应大小：-0.04）进行额外调整后，以及在对包括糖尿病、高血压和中风在内的基础疾病（OR = 0.86，CI 95%：0.81-0.92，p = .01，效应大小：-0.03）进行进一步调整后，该结果仍具有显著性：0.81-0.92, p 结论：维生素B12缺乏可能会增加TGA的风险，应将其视为TGA高危人群的潜在关注点。还需要进一步的研究来验证这些发现，并探索维生素 B12 对 TGA 影响的潜在机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Clinical Neuropsychology 医学-心理学

CiteScore

4.60

自引率

7.70%

发文量

358

审稿时长

6-12 weeks

期刊介绍： The journal publishes original contributions dealing with psychological aspects of the etiology, diagnosis, and treatment of disorders arising out of dysfunction of the central nervous system. Archives of Clinical Neuropsychology will also consider manuscripts involving the established principles of the profession of neuropsychology: (a) delivery and evaluation of services, (b) ethical and legal issues, and (c) approaches to education and training. Preference will be given to empirical reports and key reviews. Brief research reports, case studies, and commentaries on published articles (not exceeding two printed pages) will also be considered. At the discretion of the editor, rebuttals to commentaries may be invited. Occasional papers of a theoretical nature will be considered.