Markers of T-cell dysfunction and not inflammaging predict the waning of humoral responses to SARS-CoV-2 mRNA booster vaccination in people with HIV.

IF 3.4 2区医学 Q3 IMMUNOLOGY

AIDS Pub Date : 2024-11-15 Epub Date: 2024-10-31 DOI:10.1097/QAD.0000000000004010

Matteo Augello, Valeria Bono, Roberta Rovito, Andrea Santoro, Camilla Tincati, Giulia Marchetti

引用次数: 0

Abstract

In this prospective longitudinal study, we evaluated the durability of humoral responses to SARS-CoV-2 mRNA booster vaccination in 93 people with HIV, exploring the possible role of T-cell dysfunction and inflammaging biomarkers in predicting antibody waning. We found that, despite a negligible influence of the inflammaging milieu, low CD4/CD8 ratio and CD4+CD127+ percentage as well as high CD8+CD38+CD45RO+ percentage are associated with faster antibody waning, in turn contributing to our understanding of the determinants of COVID-19 vaccine-elicited immune response in this population.

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T细胞功能障碍标志物而非炎症标志物可预测 HIV 感染者对 SARS-CoV-2 mRNA 强化疫苗体液反应的减弱。

在这项前瞻性纵向研究中，我们评估了 93 名艾滋病病毒感染者对 SARS-CoV-2 mRNA 加强免疫的体液反应的持久性，探讨了 T 细胞功能障碍和炎症生物标志物在预测抗体减弱中可能发挥的作用。我们发现，尽管炎症环境的影响可以忽略不计，但低 CD4/CD8 比率和 CD4+CD127+ 百分比以及高 CD8+CD38+CD45RO+ 百分比与抗体衰减速度加快有关，这反过来又有助于我们理解 COVID-19 疫苗在这一人群中激发免疫反应的决定因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

AIDS 医学-病毒学

CiteScore

5.90

自引率

5.30%

发文量

478

审稿时长

3 months

期刊介绍： Publishing the very latest ground breaking research on HIV and AIDS. Read by all the top clinicians and researchers, AIDS has the highest impact of all AIDS-related journals. With 18 issues per year, AIDS guarantees the authoritative presentation of significant advances. The Editors, themselves noted international experts who know the demands of your work, are committed to making AIDS the most distinguished and innovative journal in the field. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.