Hepatic steatosis-insulin resistance and type 2 diabetes in people with HIV at diagnosis: effect of initial antiretroviral therapy.

IF 3.4 2区医学 Q3 IMMUNOLOGY

AIDS Pub Date : 2024-11-15 Epub Date: 2024-10-31 DOI:10.1097/QAD.0000000000004008

Maria Luisa Montes, Carmen Busca, Marta Rava, José Ignacio Bernardino, Antonio Rivero, Luz Martín-Carbonero, Esperanza Cañas-Ruano, Sofia Ibarra Ugarte, María José Galindo, Alfonso Cabello, Juan González-García

引用次数: 0

Abstract

We evaluated the impact of hepatic steatosis-insulin resistance (HS-IR) and liver fibrosis (LF) on type 2 diabetes mellitus (DM2) using triglyceride-glucose (TyG) and Fibrosis-4 (FIB-4). The incidence of DM2 was 12.9 [95% confidence interval (CI), 16.9-9.7] and 9.8 (95% CI, 6.9-13.6) per 1000 person-years in HS-IR and LF. The prevalence of HS-IR was significantly lower at 12 and 24 months with TDF + (3TC or FTC) + RPV [hazard ratio (HR) 0.5 [95% CI, 0.3-0.8], P < 0.01 at 12 months; 0.6 [0.4-0.9], P = 0.01 at 24 months].

查看原文本刊更多论文

艾滋病病毒感染者确诊时的肝脏脂肪变性-胰岛素抵抗和 2 型糖尿病：初始抗逆转录病毒疗法的影响。

我们利用甘油三酯-葡萄糖（TyG）和纤维化-4（FIB-4）评估了肝脂肪变性-胰岛素抵抗（HS-IR）和肝纤维化（LF）对 2 型糖尿病（DM2）的影响。在 HS-IR 和 LF 中，DM2 的发病率分别为每千人年 12.9 例 [95% 置信区间 (CI)，16.9-9.7] 和 9.8 例 (95% CI，6.9-13.6)。使用 TDF + (3TC 或 FTC) + RPV 治疗 12 个月和 24 个月后，HS-IR 患病率明显降低[危险比 (HR) 0.5 [95% CI, 0.3-0.8], P

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

AIDS 医学-病毒学

CiteScore

5.90

自引率

5.30%

发文量

478

审稿时长

3 months

期刊介绍： Publishing the very latest ground breaking research on HIV and AIDS. Read by all the top clinicians and researchers, AIDS has the highest impact of all AIDS-related journals. With 18 issues per year, AIDS guarantees the authoritative presentation of significant advances. The Editors, themselves noted international experts who know the demands of your work, are committed to making AIDS the most distinguished and innovative journal in the field. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.