Development and application of novel biosensors for enhanced detection in medical diagnostics

IF 4.9 2区化学 Q1 CHEMISTRY, ANALYTICAL

Microchemical Journal Pub Date : 2024-10-18 DOI:10.1016/j.microc.2024.111938

A.M. Elbasiony , Sarah Alharthi , Mohamed Mohamady Ghobashy , Waleed E. Boraie , Mohamed S. Attia , Mohamed Madani , Samera Ali Al-Gahtany , Reem Darwesh , Mohamed Shaban , A.I. Sharshir

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Abstract

Biosensors have emerged as crucial medical diagnostics and environmental monitoring tools, offering high sensitivity, specificity, and rapid detection capabilities. This review highlights recent advancements in biosensor technologies, mainly focusing on integrating nanomaterials such as carbon nanotubes (CNTs), graphene oxide, and gold nanoparticles. These nanomaterials enhance biosensor performance by increasing surface area, facilitating electron transfer, and providing tunable functionalization options essential for capturing and detecting analytes. The review explores applications of biosensors in the early detection of diseases, where detecting biomarkers at low concentrations is critical for timely medical intervention. Furthermore, the application of biosensors in environmental monitoring is discussed, emphasizing their role in detecting pollutants and ensuring safety standards. Special attention is given to epidermal biosensors for non-invasive monitoring and their distinguishing features compared to other biosensors. Despite the significant progress in biosensor development, challenges such as stability, reproducibility, and real-world integration remain. Addressing these challenges is crucial for the widespread adoption of biosensors in clinical and environmental settings.

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开发和应用新型生物传感器，提高医疗诊断中的检测能力

生物传感器具有高灵敏度、特异性和快速检测能力，已成为重要的医疗诊断和环境监测工具。本综述重点介绍生物传感器技术的最新进展，主要侧重于纳米材料的集成，如碳纳米管（CNT）、氧化石墨烯和纳米金颗粒。这些纳米材料通过增加表面积、促进电子传递以及提供捕获和检测分析物所必需的可调功能化选项来提高生物传感器的性能。本综述探讨了生物传感器在疾病早期检测中的应用，在疾病早期检测中，检测低浓度的生物标志物对于及时的医疗干预至关重要。此外，还讨论了生物传感器在环境监测中的应用，强调其在检测污染物和确保安全标准方面的作用。特别关注了用于无创监测的表皮生物传感器及其与其他生物传感器相比的显著特点。尽管生物传感器的开发取得了重大进展，但稳定性、可重复性和与现实世界的整合等挑战依然存在。应对这些挑战对于生物传感器在临床和环境中的广泛应用至关重要。

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来源期刊

Microchemical Journal 化学-分析化学

CiteScore

8.70

自引率

8.30%

发文量

1131

审稿时长

1.9 months

期刊介绍： The Microchemical Journal is a peer reviewed journal devoted to all aspects and phases of analytical chemistry and chemical analysis. The Microchemical Journal publishes articles which are at the forefront of modern analytical chemistry and cover innovations in the techniques to the finest possible limits. This includes fundamental aspects, instrumentation, new developments, innovative and novel methods and applications including environmental and clinical field. Traditional classical analytical methods such as spectrophotometry and titrimetry as well as established instrumentation methods such as flame and graphite furnace atomic absorption spectrometry, gas chromatography, and modified glassy or carbon electrode electrochemical methods will be considered, provided they show significant improvements and novelty compared to the established methods.