PH-sensitive adriamycin hydrochloride and oxaliplatin dual-loaded microspheres synergistically enhance local injections effect of hepatocellular carcinoma

IF 8.7 1区医学 Q1 ENGINEERING, BIOMEDICAL

Materials Today Bio Pub Date : 2024-10-25 DOI:10.1016/j.mtbio.2024.101311

Jialu Weng , Shiyi Wu , Yating Pan , Yifan Lai , Jinrong Zhu , Wenzhang Jin , Deyu Lu , Yizhang Chen , Zhijie Yu , Xinjie Zan , Jinglin Xia

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引用次数: 0

Abstract

Chemotherapy is the primary palliative treatment for advanced hepatocellular carcinoma (HCC). However, the systemic delivery is associated with the drawbacks including a high risk of adverse effects and a low efficacy. Therefore, local injection therapy may be beneficial. Nevertheless, the existing local drug-carrying microspheres(DOBM)have the characteristics of low loading and abrupt release, can not simultaneously load two drugs, and may cause unnecessary toxicity. In this study, we created the dual-loaded bovine serum albumin (BSA) microspheres (also known as DOBM), which were hollow and contained both oxaliplatin (OXA) and Adriamycin hydrochloride (DOX). In addition, this pH-sensitive drug delivery method exhibited a high drug loading capacity and was promising in breaking through biological barriers, making it a viable option for the treatment of HCC through local implantation. Based on physiochemical evaluation of BSA microspheres, they had a porous structure which was close to the surface. Adriamycin and oxaliplatin were successfully added to the surface of BSA microspheres. According to in vitro experimental results, the growth of human HCC (HCC-LM3 and PLC/PRF/5) cell lines was significantly inhibited by DOBM. Furthermore, in the subcutaneous PLC/PRF/5 HCC model, DOBM played an essential role in tumor development and change in the tumor microenvironment.

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PH 敏感盐酸阿霉素和奥沙利铂双载体微球协同增强肝癌局部注射效果

化疗是晚期肝细胞癌（HCC）的主要姑息治疗方法。然而，全身给药存在不良反应风险高、疗效低等缺点。因此，局部注射疗法可能是有益的。然而，现有的局部载药微球（DOBM）具有载药量低、释放突然的特点，不能同时载入两种药物，而且可能引起不必要的毒性。在这项研究中，我们创造了双载体牛血清白蛋白（BSA）微球（又称 DOBM），它是中空的，同时含有奥沙利铂（OXA）和盐酸阿霉素（DOX）。此外，这种对 pH 值敏感的给药方法具有较高的药物负载能力，并有望突破生物屏障，使其成为通过局部植入治疗 HCC 的可行选择。根据对 BSA 微球的理化评估，它们具有接近表面的多孔结构。阿霉素和奥沙利铂被成功添加到 BSA 微球表面。体外实验结果表明，DOBM 能显著抑制人 HCC（HCC-LM3 和 PLC/PRF/5）细胞株的生长。此外，在皮下 PLC/PRF/5 HCC 模型中，DOBM 对肿瘤的发展和肿瘤微环境的改变起到了至关重要的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Materials Today Bio Multiple-

CiteScore

8.30

自引率

4.90%

发文量

303

审稿时长

30 days

期刊介绍： Materials Today Bio is a multidisciplinary journal that specializes in the intersection between biology and materials science, chemistry, physics, engineering, and medicine. It covers various aspects such as the design and assembly of new structures, their interaction with biological systems, functionalization, bioimaging, therapies, and diagnostics in healthcare. The journal aims to showcase the most significant advancements and discoveries in this field. As part of the Materials Today family, Materials Today Bio provides rigorous peer review, quick decision-making, and high visibility for authors. It is indexed in Scopus, PubMed Central, Emerging Sources, Citation Index (ESCI), and Directory of Open Access Journals (DOAJ).