Avacopan rescue for Granulomatosis with Polyangiitis associated scleritis and panuveitis failing rituximab and cyclophosphamide

AJO International Pub Date : 2024-10-02 DOI:10.1016/j.ajoint.2024.100072

Elaine Hu , Sana Makhdumi , Kruti Dajee , Jennifer Cao

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引用次数: 0

Abstract

Purpose

To report the use of avacopan to achieve sustained steroid-free remission in a patient with ocular inflammation secondary to Granulomatosis with Polyangiitis (GPA) failing rituximab and cyclophosphamide.

Design

Case report

Participants

A patient with GPA-associated ocular disease failing rituximab and cyclophosphamide

Results

A 45-year-old man with a diagnosis of GPA developed nodular scleritis in the right eye. He was initially treated with steroids and rituximab with resolution of his scleritis. However, his scleritis recurred and progressed with development of panuveitis, which failed treatment with repeat rituximab dosing. All findings resolved two months after the addition of Avacopan.

Conclusion

This case report documents the second successful use of avacopan to induce steroid-free remission in a GPA patient who failed standard treatment with corticosteroids and rituximab.

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阿伐潘挽救了利妥昔单抗和环磷酰胺治疗失败的肉芽肿伴多血管炎相关性巩膜炎和泛葡萄膜炎患者的生命

目的报告一名继发于多发性肉芽肿性炎症（GPA）的眼部炎症患者在使用阿伐潘后，因无类固醇而获得持续缓解的情况。他最初接受了类固醇和利妥昔单抗治疗，巩膜炎有所缓解。然而，他的巩膜炎复发并发展为泛葡萄膜炎，再次使用利妥昔单抗治疗无效。本病例报告记录了在皮质类固醇和利妥昔单抗标准治疗失败的 GPA 患者中第二次成功使用阿伐潘诱导无类固醇缓解的病例。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

AJO International

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