A continuous flow microreactor as a practical tool for the synthesis of active pharmaceutical ingredients

IF 6.9 2区环境科学与生态学 Q1 ENGINEERING, CHEMICAL

Process Safety and Environmental Protection Pub Date : 2024-10-24 DOI:10.1016/j.psep.2024.09.122

K. Vijaya Bhaskar , Mohammad Rashed , K. Subrahmanya Bhat , Jechan Lee , Ki-Hyun Kim , Kezia Buruga

引用次数: 0

Abstract

Continuous flow processing has become a key technology to maximize the capabilities of chemical syntheses. Numerous new tactics have been devised to synthesize various chemicals including active pharmaceutical ingredients (APIs) via a continuous flow system using microreactors. This review aims to illustrate the holistic system approach and diverse applications of continuous flow microreactors for the synthesis of APIs (with respect to type, design, and fabrication). This review also highlights the applicability of continuous flow microreactors in the synthesis of APIs in contrast to conventional batch-type methods along with a discussion of their merits and demerits. Overall, this review is expected to offer valuable insights into the utility of continuous flow microreactor technology for the upscaled production of commercially feasible APIs.

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作为活性药物成分合成实用工具的连续流微反应器

连续流加工已成为最大限度提高化学合成能力的一项关键技术。人们设计了许多新方法，利用微反应器通过连续流系统合成各种化学品，包括活性药物成分 (API)。本综述旨在说明用于合成原料药的连续流微反应器（在类型、设计和制造方面）的整体系统方法和各种应用。与传统的间歇式方法相比，本综述还强调了连续流微反应器在合成原料药方面的适用性，并对其优缺点进行了讨论。总之，本综述有望为连续流微反应器技术在大规模生产商业上可行的原料药方面的应用提供有价值的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Process Safety and Environmental Protection 环境科学-工程：化工

CiteScore

11.40

自引率

15.40%

发文量

929

审稿时长

8.0 months

期刊介绍： The Process Safety and Environmental Protection (PSEP) journal is a leading international publication that focuses on the publication of high-quality, original research papers in the field of engineering, specifically those related to the safety of industrial processes and environmental protection. The journal encourages submissions that present new developments in safety and environmental aspects, particularly those that show how research findings can be applied in process engineering design and practice. PSEP is particularly interested in research that brings fresh perspectives to established engineering principles, identifies unsolved problems, or suggests directions for future research. The journal also values contributions that push the boundaries of traditional engineering and welcomes multidisciplinary papers. PSEP's articles are abstracted and indexed by a range of databases and services, which helps to ensure that the journal's research is accessible and recognized in the academic and professional communities. These databases include ANTE, Chemical Abstracts, Chemical Hazards in Industry, Current Contents, Elsevier Engineering Information database, Pascal Francis, Web of Science, Scopus, Engineering Information Database EnCompass LIT (Elsevier), and INSPEC. This wide coverage facilitates the dissemination of the journal's content to a global audience interested in process safety and environmental engineering.