A study on insecticidal activity of the fennel (Foeniculum vulgare) essential oil and its nanoemulsion against stored product pests and molecular docking evaluation

IF 5.6 1区农林科学 Q1 AGRICULTURAL ENGINEERING

Industrial Crops and Products Pub Date : 2024-10-22 DOI:10.1016/j.indcrop.2024.119859

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引用次数: 0

Abstract

The granary weevil (Sitophilus granarius) the red flour beetle (Tribolium castaneum), the sawtoothed grain beetle (Oryzaephilus surinamensis) are major pests for stored products worldwide. The development of resistance to chemical pesticides and increasing concerns about human and environmental health require the investigation of alternative control approaches. Therefore, this study focuses on formulating and characterization of the fennel (Foeniculum vulgare) essential oil nanoemulsion (FEO-N) and investigate its insecticidal properties against these pests. The major chemical components of the FEO were found as estragole (54.1 %), limonene (10.89 %), p-anisaldehyde (9.04 %) using GC-MS. The FEO-N (4:3:3:90 w/w FEO: Tween 80: Ethanol: water) was formed using an ultrasonic homogenizer and characterized with TEM (spherical shape, ∼100 nm), zeta sizer (the mean droplet particle size of 107.3±1.677 nm, the ζ-potential value of −21.7±0.755 mV), as well as FT-IR analysis. Five hundred ppm of the FEO-N caused 23.33 %, 63.33 % and 20 % mortality in T. castaneum, O. surinamensis and S. granarius after 7 days, respectively. One thousand ppm of the FEO-N caused 76.67 %, 100 % and 63.33 % mortality in T. castaneum, O. surinamensis and S. granarius after 7 days, respectively. Overall, these results clearly showed the potential insecticidal activity of the FEO-N against pests. Afterwards, the interactions of the molecules found in the FEO against Tribolium castaneum (PDB ID: 6V3T and 7LT2) were examined and benzenemethanol, 4-methoxy-.alpha.-(2-nitrocyclopentyl) molecule appears to have the highest activity against 6V3T and 7LT2 proteins. The drug properties of the molecules showing the best activity of the molecules found in the FEO were examined by ADME/T analysis.

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茴香（Foeniculum vulgare）精油及其纳米乳液对储藏产品害虫的杀虫活性研究及分子对接评估

粮仓象鼻虫（Sitophilus granarius）、红面粉甲虫（Tribolium castaneum）和锯齿谷物甲虫（Oryzaephilus surinamensis）是全球储藏产品的主要害虫。由于对化学杀虫剂产生抗药性，以及对人类和环境健康的日益关注，需要研究替代的防治方法。因此，本研究侧重于茴香（Foeniculum vulgare）精油纳米乳液（FEO-N）的配制和表征，并研究其对这些害虫的杀虫特性。通过气相色谱-质谱（GC-MS）分析发现，茴香精油的主要化学成分为雌甾醇（54.1%）、柠檬烯（10.89%）和对甲氧基苯甲醛（9.04%）。FEO-N （4:3:3:90 w/w FEO：吐温 80：乙醇：水）是用超声波均质机制成的，并用 TEM（球形，∼100 nm）、zeta 分析仪（平均液滴粒径为 107.3±1.677 nm，ζ电位值为 -21.7±0.755 mV）和傅立叶变换红外分析进行了表征。5 百万分之(ppm)的 FEO-N 在 7 天后分别导致 23.33 %、63.33 % 和 20 % 的 T. castaneum、O. surinamensis 和 S. granarius 死亡。1,000 ppm 的 FEO-N 会在 7 天后分别导致 76.67 %、100 % 和 63.33 % 的蓖麻蝇、苏里南蓖麻蝇和花斑蓖麻蝇死亡。总之，这些结果清楚地表明了 FEO-N 对害虫的潜在杀虫活性。随后，研究了 FEO 中发现的分子对蓖麻毛虫（PDB ID：6V3T 和 7LT2）的相互作用，发现苯甲醇、4-甲氧基-α.-（2-硝基环戊基）分子似乎对 6V3T 和 7LT2 蛋白具有最高的活性。通过 ADME/T 分析，研究了在 FEO 中发现的活性最好的分子的药物特性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Industrial Crops and Products 农林科学-农业工程

CiteScore

9.50

自引率

8.50%

发文量

1518

审稿时长

43 days

期刊介绍： Industrial Crops and Products is an International Journal publishing academic and industrial research on industrial (defined as non-food/non-feed) crops and products. Papers concern both crop-oriented and bio-based materials from crops-oriented research, and should be of interest to an international audience, hypothesis driven, and where comparisons are made statistics performed.